{"id":"W4280554281","doi":"10.1164/rccm.202108-1901oc","title":"Increased SARS-CoV-2 Infection, Protease, and Inflammatory Responses in Chronic Obstructive Pulmonary Disease Primary Bronchial Epithelial Cells Defined with Single-Cell RNA Sequencing","year":2022,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Respiratory viral infections research","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; Sydney Partnership for Health, Education, Research and Enterprise; Institute of Infection and Immunity; University of Technology Sydney","keywords":"Immunology; Medicine; COPD; Proteases; Proinflammatory cytokine; Immune system; Virology; Inflammation; Biology; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002970157,0.0002095134,0.000338613,0.0003034562,0.0002477785,0.0003736435,0.0001147381,0.0002940586,0.0009218745],"category_scores_gemma":[0.0002411711,0.0001571096,0.0002313738,0.0002942019,0.0002487058,0.0001319237,0.0001918525,0.000314951,0.0003027961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000197504,"about_ca_system_score_gemma":0.0001561527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00048684,"about_ca_topic_score_gemma":0.000920707,"domain_scores_codex":[0.9996722,0.00005205501,0.00002781803,0.00009452599,0.0001099309,0.00004361857],"domain_scores_gemma":[0.9998384,0.00003883,0.00003398425,0.00002577953,0.00003730668,0.00002577227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009021723,0.00001151537,0.001975561,0.00002981541,0.000004781196,0.00002990714,0.00002197853,0.00003713296,0.9972301,0.00001507457,0.00001591833,0.0005379806],"study_design_scores_gemma":[0.00002571951,0.0008376961,0.2211214,0.0000208679,0.00004792054,0.0009531047,0.0002830731,0.002555135,0.7716675,0.0001281744,0.002345158,0.0000142272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913056,0.001157975,0.005105259,0.00005026111,0.00002371325,0.00007975222,0.001340055,0.00004411604,0.0008931868],"genre_scores_gemma":[0.9865924,0.0007764353,0.008452353,0.0001300574,0.00001983427,0.0001966306,0.002519743,0.00001545518,0.001297078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009218745,"threshold_uncertainty_score":0.003084004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0276057523316206,"score_gpt":0.3088827380651932,"score_spread":0.2812769857335726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}