{"id":"W4280559566","doi":"10.1016/j.devcel.2022.04.020","title":"DRP1 levels determine the apoptotic threshold during embryonic differentiation through a mitophagy-dependent mechanism","year":2022,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of General Medical Sciences; Biotechnology and Biological Sciences Research Council; Medical Research Council; Manchester Biomedical Research Centre; National Institutes of Health; Barwon Health Foundation; Innovative Medicines Initiative; European Commission; H2020 Marie Skłodowska-Curie Actions; BHF Centre of Research Excellence, Oxford; Diabetes UK; National Heart and Lung Institute; Wellcome Trust; British Heart Foundation; Cancer Research UK; Breast Cancer Now; European Molecular Biology Organization","keywords":"Mitophagy; Biology; Cell biology; Embryonic stem cell; Apoptosis; Mitochondrial fission; Germline; DNM1L; Embryoid body; Programmed cell death; Induced pluripotent stem cell; Cellular differentiation; Mitochondrion; Genetics; Autophagy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001387598,0.0002433453,0.0002428451,0.00007138007,0.0006783097,0.00003331211,0.0002573871,0.00005022698,0.002539815],"category_scores_gemma":[0.000005421959,0.0001900136,0.0001352906,0.0001975186,0.00003525761,0.0001028674,0.0002963672,0.0003266823,0.0001165975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004024137,"about_ca_system_score_gemma":0.0001671689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001071363,"about_ca_topic_score_gemma":0.000002917615,"domain_scores_codex":[0.9982515,0.00006122913,0.0003024472,0.0003717185,0.00063473,0.000378354],"domain_scores_gemma":[0.9994382,0.00003150821,0.0001206175,0.0002894746,0.00002492349,0.00009524837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008608589,0.001870418,0.005396102,0.0003947298,0.0006421894,0.0009416792,0.009338032,0.00007095276,0.9749276,0.002635339,0.0008612153,0.002060876],"study_design_scores_gemma":[0.003948989,0.0001794983,0.07248842,0.00003243103,0.0001200531,0.0003102905,0.001532822,0.0002158396,0.9171309,0.002709065,0.0009469536,0.0003846974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994449,0.0005077267,0.0001680907,0.0002674071,0.0004755812,0.0006670812,0.00002602767,0.0001053802,0.003333678],"genre_scores_gemma":[0.9919112,0.00006903708,0.0003683164,0.001119424,0.0001062443,0.0002239934,0.00008127545,0.0000484979,0.006071981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06709232,"threshold_uncertainty_score":0.998372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02148476539956,"score_gpt":0.2407428934072253,"score_spread":0.2192581280076653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}