{"id":"W4280561406","doi":"10.1016/j.omto.2022.04.004","title":"Dependency of EGFR activation in vanadium-based sensitization to oncolytic virotherapy","year":2022,"lang":"en","type":"article","venue":"Molecular Therapy — Oncolytics","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Ministère de l’Éducation, Gouvernement de l’Ontario; University of Ottawa; Terry Fox Research Institute; Canadian Cancer Society; Lotte and John Hecht Memorial Foundation; Colorado State University","keywords":"Oncolytic virus; Vanadate; Cancer research; Virotherapy; Sodium orthovanadate; Epidermal growth factor receptor; Kinase; Biology; Cell biology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002095302,0.0001575586,0.0001675916,0.0001966793,0.00007891162,0.00001450407,0.000181502,0.00008003992,0.000131751],"category_scores_gemma":[0.00004793607,0.000183418,0.0001029009,0.0004235147,0.00002717774,0.000004952332,0.00004539422,0.00008643355,0.000003790242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001546455,"about_ca_system_score_gemma":0.0003260782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005409713,"about_ca_topic_score_gemma":0.00003911544,"domain_scores_codex":[0.9986683,0.0001902088,0.0002991819,0.0003077726,0.0003340592,0.0002005374],"domain_scores_gemma":[0.999274,0.00001853996,0.0001268411,0.0003849717,0.00008709616,0.000108592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006217622,0.0003272063,0.002352695,0.000009278189,0.00002437376,0.000008039943,0.0000837023,0.07183705,0.9187059,0.0002849748,0.0001475159,0.005597519],"study_design_scores_gemma":[0.004762208,0.001454125,0.008891117,0.00002063851,0.00001369969,0.000004513315,0.0001299821,0.007471957,0.9580662,0.0005509324,0.018175,0.0004596726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.969806,0.000134658,0.02777554,0.000929879,0.00007802337,0.0006537872,0.00001766829,0.00001178936,0.000592639],"genre_scores_gemma":[0.9949804,0.00001918458,0.0009663595,0.003423033,0.00003955697,0.00008917767,0.0001632629,0.00004176562,0.0002772366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06436508,"threshold_uncertainty_score":0.7479569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00979807380116661,"score_gpt":0.2612002449714459,"score_spread":0.2514021711702794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}