{"id":"W4280565406","doi":"10.1038/s41586-022-04758-2","title":"PHGDH heterogeneity potentiates cancer cell dissemination and metastasis","year":2022,"lang":"en","type":"article","venue":"Nature","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":210,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Institute for Research in Immunology and Cancer; Université de Montréal; McGill University Health Centre","funders":"National Cancer Institute; National Institutes of Health; Dr. Rolf M. Schwiete Stiftung; Kom op tegen Kanker; Koning Boudewijnstichting; Fonds Baillet Latour; Boehringer Ingelheim Stiftung; Deutsche Krebshilfe; Fonds Wetenschappelijk Onderzoek; KU Leuven; McGill University; McGill University Health Centre; Bayer; Cancer Prevention and Research Institute of Texas; Cancer Research UK","keywords":"Metastasis; Cancer research; Cancer metastasis; Cancer cell; Cancer; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009755955,0.0002529006,0.0002498445,0.000163662,0.00009414562,0.0002102065,0.0001274159,0.0002327787,0.001491548],"category_scores_gemma":[0.0001152722,0.00009428461,0.0001676232,0.000105273,0.0002161744,0.0001465632,0.0003577269,0.0004829715,0.0001876727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004116205,"about_ca_system_score_gemma":0.0001285352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004324076,"about_ca_topic_score_gemma":0.0005633743,"domain_scores_codex":[0.9998771,0.0000192854,0.000004234542,0.00002249516,0.0000452869,0.00003153047],"domain_scores_gemma":[0.9999092,0.00001893617,0.00001942246,0.000009971231,0.000007902991,0.00003465745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007451516,0.00001524837,0.0002486595,0.00004050921,0.000004444861,0.00005356367,0.000005727238,0.00005925584,0.9979224,0.0001306181,0.00007363805,0.001371618],"study_design_scores_gemma":[0.00002862007,0.0006527849,0.01404861,0.000007685544,0.00002154151,0.0005488271,0.00002412871,0.001074377,0.9759714,0.0001556969,0.007460141,0.000006205908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890998,0.004579728,0.00304916,0.000223094,0.0000520726,0.00004876472,0.0002836031,0.0001120295,0.002551649],"genre_scores_gemma":[0.9964898,0.00128954,0.0005337748,0.00005649109,0.00001446212,0.00002045304,0.0001575161,0.000009702025,0.001428271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001491548,"threshold_uncertainty_score":0.004989743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004637471905795062,"score_gpt":0.2655871587133442,"score_spread":0.2609496868075492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}