{"id":"W4280565406","doi":"10.1038/s41586-022-04758-2","title":"PHGDH heterogeneity potentiates cancer cell dissemination and metastasis","year":2022,"lang":"en","type":"article","venue":"Nature","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":210,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Institute for Research in Immunology and Cancer; Université de Montréal; McGill University Health Centre","funders":"National Cancer Institute; National Institutes of Health; Dr. Rolf M. Schwiete Stiftung; Kom op tegen Kanker; Koning Boudewijnstichting; Fonds Baillet Latour; Boehringer Ingelheim Stiftung; Deutsche Krebshilfe; Fonds Wetenschappelijk Onderzoek; KU Leuven; McGill University; McGill University Health Centre; Bayer; Cancer Prevention and Research Institute of Texas; Cancer Research UK","keywords":"Metastasis; Cancer research; Cancer metastasis; Cancer cell; Cancer; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009481378,0.00009432785,0.00009017887,0.00001821893,0.0001461155,0.000015491,0.00009873537,0.0002108029,0.0001183215],"category_scores_gemma":[0.00001238824,0.00009188757,0.0000599493,0.00006129379,0.00001975692,0.000003651467,0.000142485,0.0003346179,4.528492e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001686938,"about_ca_system_score_gemma":0.00002924244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000540393,"about_ca_topic_score_gemma":0.0001462424,"domain_scores_codex":[0.9993685,0.00004098496,0.00007292192,0.0002525795,0.0001322517,0.0001327805],"domain_scores_gemma":[0.9997115,0.000004246442,0.00004723659,0.0001517708,0.00003925612,0.00004598241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000523446,0.00005542761,0.0008439748,0.00002154573,0.00005614495,8.177407e-7,0.0000699341,0.00004158959,0.9461604,0.00003131497,0.03229161,0.02037485],"study_design_scores_gemma":[0.0002560335,0.00004249971,0.004403963,0.000001738091,0.00005317348,0.000009373462,0.00009931975,0.00001577136,0.4069405,0.00001873182,0.5880319,0.0001269185],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8728206,0.1252097,0.00002581136,0.0002223277,0.0009932866,0.00009837268,0.0002524598,0.000008529057,0.0003688827],"genre_scores_gemma":[0.9927931,0.004494279,0.0001297308,0.0005803419,0.0004691377,0.00005571131,0.000197469,0.00001434548,0.001265905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5557404,"threshold_uncertainty_score":0.3747066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004637471905795062,"score_gpt":0.2655871587133442,"score_spread":0.2609496868075492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}