{"id":"W4280568048","doi":"10.1200/jco.22.00098","title":"Circulating Tumor DNA as a Biomarker in Patients With Stage III and IV Wilms Tumor: Analysis From a Children's Oncology Group Trial, AREN0533","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; BC Children's Hospital","funders":"National Cancer Institute","keywords":"Medicine; Circulating tumor DNA; Liquid biopsy; Wilms' tumor; Urine; Internal medicine; Biomarker; Oncology; Stage (stratigraphy); Cancer; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002845777,0.0004020172,0.0007196657,0.000380476,0.0003430374,0.0006404454,0.0003650577,0.0004724692,0.0006574015],"category_scores_gemma":[0.003744504,0.0001935321,0.0006253956,0.0007872608,0.0004107371,0.0003336915,0.0003307772,0.0006744569,0.00008960522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007524657,"about_ca_system_score_gemma":0.0007431513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00191482,"about_ca_topic_score_gemma":0.003524287,"domain_scores_codex":[0.9984645,0.0008076297,0.00008731105,0.0002636125,0.0002688447,0.0001080831],"domain_scores_gemma":[0.9969819,0.0009434361,0.001065029,0.0002720889,0.0001964343,0.0005410809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03632419,0.000337274,0.9485218,0.0001033414,0.001070976,0.0002036851,0.0001351321,0.0005689613,0.003275053,0.00008403219,0.001003121,0.008372515],"study_design_scores_gemma":[0.003735564,0.005853643,0.9854482,0.00002534127,0.0006932534,0.0005027765,0.00006806822,0.0011363,0.0009448809,0.0000590211,0.001515654,0.00001733416],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989575,0.0004054332,0.00005751615,0.00005159227,0.000008107965,0.00003412389,0.0003301034,0.00000293398,0.0001526449],"genre_scores_gemma":[0.997738,0.0001700574,0.000246545,0.00009669502,0.00002260515,0.00006765507,0.001533293,0.000003840564,0.0001212957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002845777,"threshold_uncertainty_score":0.01505011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02797887628225295,"score_gpt":0.352040121269975,"score_spread":0.3240612449877221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}