{"id":"W4280568048","doi":"10.1200/jco.22.00098","title":"Circulating Tumor DNA as a Biomarker in Patients With Stage III and IV Wilms Tumor: Analysis From a Children's Oncology Group Trial, AREN0533","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; BC Children's Hospital","funders":"National Cancer Institute","keywords":"Medicine; Circulating tumor DNA; Liquid biopsy; Wilms' tumor; Urine; Internal medicine; Biomarker; Oncology; Stage (stratigraphy); Cancer; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001962865,0.0001916945,0.001246831,0.0002169525,0.0001021934,0.00002151829,0.0002820573,0.0001884398,0.0001481231],"category_scores_gemma":[0.001277229,0.0001633657,0.0003661704,0.0003129594,0.000175976,0.000009326779,0.0003347856,0.000622623,0.000001003446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001656829,"about_ca_system_score_gemma":0.001159601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004770377,"about_ca_topic_score_gemma":0.0009478434,"domain_scores_codex":[0.996485,0.000702185,0.001796037,0.0004355872,0.0002967197,0.0002844677],"domain_scores_gemma":[0.9964789,0.0008028208,0.002042923,0.0002703419,0.000146592,0.0002584262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.08181662,0.003805878,0.8881632,0.000005359694,0.002619175,0.0006197581,0.0001263384,0.0007261763,0.001066254,0.00003463074,0.001014087,0.02000249],"study_design_scores_gemma":[0.07708161,0.03028842,0.8684322,0.00001103383,0.0008219715,0.00006026996,0.0002815046,0.0002199275,0.00002717203,0.0001230142,0.02237137,0.000281479],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979461,0.0004332811,0.00008591173,0.0003000621,0.0005298938,0.0003312392,0.0001120208,0.000002665164,0.0002587768],"genre_scores_gemma":[0.9964589,0.0001444152,0.0008446387,0.002002922,0.0003522287,0.00002048275,0.0001327054,0.00002225545,0.00002138589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02648254,"threshold_uncertainty_score":0.6661862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02797887628225295,"score_gpt":0.352040121269975,"score_spread":0.3240612449877221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}