{"id":"W4280569737","doi":"10.1164/rccm.202108-1907oc","title":"Pulmonary Function and Blood DNA Methylation: A Multiancestry Epigenome-Wide Association Meta-analysis","year":2022,"lang":"en","type":"review","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"National Institute of Environmental Health Sciences; National Heart, Lung, and Blood Institute; Economic and Social Research Council; Biotechnology and Biological Sciences Research Council; National Institutes of Health; Wellcome Trust","keywords":"DNA methylation; Epigenome; Epigenomics; Genome-wide association study; Genetics; Medicine; Epigenetics; Genetic association; Bioinformatics; Biology; Gene; Single-nucleotide polymorphism; Genotype; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007569769,0.001688494,0.003356979,0.002908746,0.000787517,0.001651675,0.001507797,0.0009288799,0.002357103],"category_scores_gemma":[0.0106215,0.0007940109,0.01630242,0.004840565,0.0004406714,0.0006985199,0.00137278,0.001475258,0.0001875948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006068031,"about_ca_system_score_gemma":0.001004744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009504531,"about_ca_topic_score_gemma":0.01107675,"domain_scores_codex":[0.9925705,0.004202032,0.0005284313,0.001934423,0.0004608634,0.0003037421],"domain_scores_gemma":[0.9943961,0.003514278,0.0005554389,0.001076804,0.0002942841,0.0001629701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.003739826,0.00005467649,0.3886837,0.003353466,0.5750123,0.0006558931,0.0001439069,0.006754383,0.00543226,0.0005569593,0.00156905,0.01404357],"study_design_scores_gemma":[0.0007262589,0.0006837872,0.3303563,0.0007438689,0.638552,0.0008793442,0.00018901,0.01898253,0.002862993,0.00210251,0.003833254,0.00008800224],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.7367745,0.1790051,0.06408034,0.002373365,0.0005255481,0.0003372584,0.014006,0.0008089014,0.002088946],"genre_scores_gemma":[0.9836974,0.006415404,0.007296026,0.0002386124,0.00009141179,0.0001677883,0.001634145,0.00008495136,0.0003743514],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.009504531,"threshold_uncertainty_score":0.04003328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05831935933077461,"score_gpt":0.3510607141183087,"score_spread":0.2927413547875341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}