{"id":"W4280578054","doi":"10.3389/fcell.2022.865948","title":"Thyroid Hormones Deficiency Impairs Male Germ Cell Development: A Cross Talk Between Hypothalamic-Pituitary-Thyroid, and—Gonadal Axes in Zebrafish","year":2022,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Reproductive biology and impacts on aquatic species","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Zebrafish; Biology; Internal medicine; Endocrinology; Hormone; Thyroid; Germ cell; Triiodothyronine; Spermatogenesis; Hypothalamic–pituitary–gonadal axis; Hypothalamic–pituitary–thyroid axis; Luteinizing hormone; Gene; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001446352,0.0004172442,0.0003020479,0.0003027545,0.0002337207,0.00024086,0.0002260724,0.0003198491,0.001685004],"category_scores_gemma":[0.000129275,0.0002332895,0.0004150002,0.0001458788,0.0004708195,0.0002906581,0.000263651,0.0005654956,0.0001693147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005739013,"about_ca_system_score_gemma":0.0006149837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00566346,"about_ca_topic_score_gemma":0.01219681,"domain_scores_codex":[0.9998665,0.00001019523,0.00001562761,0.00003969471,0.00004233615,0.00002570427],"domain_scores_gemma":[0.9998872,0.00001124992,0.00004043956,0.000006728123,0.00001153748,0.00004283584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000721777,0.000007478618,0.000305746,0.00004264894,0.000004526362,0.00006984318,0.00002492609,0.00002404635,0.9989263,0.00005363367,0.00002706592,0.0004415452],"study_design_scores_gemma":[0.00006562999,0.0008699852,0.06477126,0.00002633385,0.00007669075,0.0004391106,0.0001946189,0.0007374682,0.9291839,0.0001615291,0.003449264,0.00002419694],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934828,0.00267053,0.001407259,0.00025662,0.0000565162,0.00003103514,0.0007944602,0.00009995744,0.001200806],"genre_scores_gemma":[0.990211,0.001641663,0.001476777,0.0001973706,0.00001195646,0.00008099982,0.0004726594,0.00003953313,0.00586796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00566346,"threshold_uncertainty_score":0.01126099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007911321900056533,"score_gpt":0.2169079628686215,"score_spread":0.208996640968565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}