{"id":"W4280578054","doi":"10.3389/fcell.2022.865948","title":"Thyroid Hormones Deficiency Impairs Male Germ Cell Development: A Cross Talk Between Hypothalamic-Pituitary-Thyroid, and—Gonadal Axes in Zebrafish","year":2022,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Reproductive biology and impacts on aquatic species","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Zebrafish; Biology; Internal medicine; Endocrinology; Hormone; Thyroid; Germ cell; Triiodothyronine; Spermatogenesis; Hypothalamic–pituitary–gonadal axis; Hypothalamic–pituitary–thyroid axis; Luteinizing hormone; Gene; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005934929,0.0003367387,0.0004083685,0.0002427414,0.0003751736,0.00002705424,0.000295326,0.000241528,0.00005522538],"category_scores_gemma":[0.0000690513,0.0003219266,0.00004722919,0.0002190739,0.0004827859,0.0000200519,0.0006356413,0.0002875209,0.000004395828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001246899,"about_ca_system_score_gemma":0.000250994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009437174,"about_ca_topic_score_gemma":0.00006748713,"domain_scores_codex":[0.9976661,0.0002062911,0.0005150976,0.000879915,0.0001143527,0.0006182615],"domain_scores_gemma":[0.9994957,0.00004277089,0.0001435949,0.0001824647,0.00002452544,0.0001108762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001935214,0.0001364577,0.7746386,0.00002493511,0.00002572745,0.00001918995,0.0008188661,0.000005769381,0.2186599,0.00001042767,0.001932899,0.003533701],"study_design_scores_gemma":[0.002942146,0.0010348,0.7373108,0.000008348699,0.00001269237,0.0001936674,0.006305369,0.00001209906,0.2207105,0.0007723518,0.0297499,0.0009473737],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854172,0.01113104,0.0001550515,0.00007667221,0.0003654454,0.0003338252,0.00008253173,0.00001270109,0.002425463],"genre_scores_gemma":[0.9916458,0.000610318,0.005781589,0.0002050756,0.00005589123,0.00008304671,0.0004329016,0.00002229305,0.001163148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03732781,"threshold_uncertainty_score":0.9999233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007911321900056533,"score_gpt":0.2169079628686215,"score_spread":0.208996640968565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}