{"id":"W4280580246","doi":"10.1038/s41467-022-30376-7","title":"Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Novo Nordisk; Danmarks Grundforskningsfond; Statens Naturvidenskabelige Forskningsrad; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Horizon 2020 Framework Programme; National Research Foundation; Natural Sciences and Engineering Research Council of Canada; European Commission","keywords":"Deubiquitinating enzyme; Ubiquitin; Proteasome; Enzyme; Cell biology; Chemistry; Ubiquitins; Ubiquitin-Protein Ligases; Biochemistry; Biology; Ubiquitin ligase; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006675817,0.0001131605,0.0001388023,0.00003734294,0.0005901451,0.00002414401,0.000839825,0.0001186774,0.00003628684],"category_scores_gemma":[0.0001928462,0.00009170474,0.00007415067,0.0001318211,0.0003556052,0.000004663442,0.00119538,0.0005826958,6.247869e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009125508,"about_ca_system_score_gemma":0.00008273215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001855885,"about_ca_topic_score_gemma":0.00006272453,"domain_scores_codex":[0.9987402,0.0005315092,0.0002309705,0.000186291,0.0001606416,0.0001503864],"domain_scores_gemma":[0.9985449,0.0001131252,0.000189374,0.001011641,0.000106424,0.00003451144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007524652,0.0003214655,0.003667901,0.0001354994,0.0003303238,0.000001154382,0.002353081,0.0000838313,0.6224455,0.3554026,0.003737109,0.01076914],"study_design_scores_gemma":[0.002506224,0.0003027286,0.004329482,0.0000360013,0.00008219692,0.00008041629,0.001289841,0.0007007181,0.9041273,0.004667893,0.0815048,0.0003724165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9642224,0.02583194,0.00002655717,0.003257619,0.00008146244,0.0008841142,0.0001738209,0.00002651751,0.005495595],"genre_scores_gemma":[0.997026,0.0003550219,0.00148844,0.0002366331,0.00004118099,0.0003590256,0.0002781127,0.00001666905,0.0001989408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3507347,"threshold_uncertainty_score":0.4538979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01633522211758963,"score_gpt":0.2739234953869772,"score_spread":0.2575882732693876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}