{"id":"W4280580246","doi":"10.1038/s41467-022-30376-7","title":"Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Novo Nordisk; Danmarks Grundforskningsfond; Statens Naturvidenskabelige Forskningsrad; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Horizon 2020 Framework Programme; National Research Foundation; Natural Sciences and Engineering Research Council of Canada; European Commission","keywords":"Deubiquitinating enzyme; Ubiquitin; Proteasome; Enzyme; Cell biology; Chemistry; Ubiquitins; Ubiquitin-Protein Ligases; Biochemistry; Biology; Ubiquitin ligase; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002416345,0.000468471,0.0003668729,0.0004364773,0.0002292384,0.0008938157,0.0001880004,0.0003144341,0.0008533079],"category_scores_gemma":[0.0001835076,0.0002040684,0.0002773053,0.0003127571,0.0003290118,0.0006608634,0.0003314963,0.00032406,0.0004129491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003622386,"about_ca_system_score_gemma":0.0001451894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001498964,"about_ca_topic_score_gemma":0.0003472084,"domain_scores_codex":[0.999772,0.00002719532,0.00001315677,0.00008659948,0.00005148574,0.00004956381],"domain_scores_gemma":[0.9998447,0.00002507055,0.00005985497,0.00002365585,0.00001850295,0.00002822322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001728297,0.00002005659,0.004222931,0.00009561529,0.00003752943,0.0001511197,0.00003376639,0.0005031235,0.9864087,0.0008813493,0.00007912096,0.00739385],"study_design_scores_gemma":[0.00001021572,0.0001395684,0.05677456,0.00001470387,0.00004483447,0.0006814488,0.0001092881,0.001859087,0.934577,0.001057768,0.004718579,0.00001300162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9736273,0.01142439,0.01127214,0.0001156093,0.0000218436,0.00001770996,0.0004089447,0.0001199133,0.002992235],"genre_scores_gemma":[0.9919505,0.003838391,0.002747268,0.00004256043,0.0000103414,0.00001291225,0.0002568697,0.00001527074,0.001125926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008938157,"threshold_uncertainty_score":0.002854586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01633522211758963,"score_gpt":0.2739234953869772,"score_spread":0.2575882732693876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}