{"id":"W4280580357","doi":"10.1038/s41591-022-01805-3","title":"Empagliflozin add-on therapy to closed-loop insulin delivery in type 1 diabetes: a 2 × 2 factorial randomized crossover trial","year":2022,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Diabetes Management and Research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; McGill University; Sinai Health System; McGill University Health Centre","funders":"Canadian Institutes of Health Research; University of Toronto; Government of Canada; Juvenile Diabetes Research Foundation United States of America; Diabetes Action Research and Education Foundation","keywords":"Crossover study; Randomized controlled trial; Type 2 diabetes; Medicine; Empagliflozin; Closed loop; Insulin; Diabetes mellitus; Insulin delivery; Internal medicine; Type 1 diabetes; Endocrinology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002648319,0.0003273953,0.001252046,0.0009302472,0.0001482592,0.00002509316,0.0003686135,0.0002686545,0.004901159],"category_scores_gemma":[0.002684211,0.0002174103,0.0002012705,0.001596884,0.0001397936,0.00006076952,0.0002084946,0.002156931,0.00007808865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002635905,"about_ca_system_score_gemma":0.0001788953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003588438,"about_ca_topic_score_gemma":0.00001111326,"domain_scores_codex":[0.9959103,0.0005154524,0.0005968948,0.0005716102,0.001762939,0.000642786],"domain_scores_gemma":[0.9981129,0.0007972901,0.0001202677,0.0005181286,0.0001829306,0.000268535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8655101,0.0006828213,0.0003938215,0.00004572333,0.0002795369,0.0001101409,0.0007968613,0.00002421859,0.002235283,0.0002122733,0.1085066,0.0212026],"study_design_scores_gemma":[0.7417364,0.005977344,0.0006740501,0.0001403158,0.00008231543,5.011149e-7,0.0001410719,0.0001306821,0.0004858755,0.000213343,0.2502054,0.0002127276],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9668525,0.00522409,0.000001879606,0.009140611,0.006653376,0.004537908,0.00001500166,0.00008906154,0.007485526],"genre_scores_gemma":[0.9782366,0.0002732154,0.0000272126,0.0107781,0.003870279,0.0003899227,0.0001737969,0.00005888551,0.006191957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1416988,"threshold_uncertainty_score":0.9960085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02357465963414282,"score_gpt":0.3369397572504202,"score_spread":0.3133650976162774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}