{"id":"W4280584397","doi":"10.1126/science.abm6380","title":"Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin","year":2022,"lang":"en","type":"article","venue":"Science","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Biotech; National Cancer Institute; National Institutes of Health; Honjo International Scholarship Foundation; European Molecular Biology Organization; Fondation pour la Recherche Médicale; Memorial Sloan-Kettering Cancer Center; Institut National de la Santé et de la Recherche Médicale; European Commission; York University; Lastentautien Tutkimussäätiö; Institut des maladies génétiques Imagine; Cystic Fibrosis Foundation; KU Leuven; St. Giles Foundation; National Center for Advancing Translational Sciences; Fondation Bettencourt Schueller; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Agence Nationale de la Recherche; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute","keywords":"Haploinsufficiency; Biology; Immunology; Staphylococcus aureus; Tumor necrosis factor alpha; Toxin; Microbiology; Gene; Genetics; Phenotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009714587,0.0004967282,0.0002294437,0.0003255159,0.0001896651,0.0001640589,0.0001165057,0.0003390294,0.001140126],"category_scores_gemma":[0.0002322471,0.00008078825,0.0001028648,0.0001495823,0.0003441473,0.00009252784,0.0002117401,0.0001989633,0.0001132013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000147696,"about_ca_system_score_gemma":0.00007742794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004337853,"about_ca_topic_score_gemma":0.0005360857,"domain_scores_codex":[0.9998952,0.00001480006,0.00001477557,0.00003040436,0.00002249634,0.0000222879],"domain_scores_gemma":[0.9998548,0.00005857378,0.00003507059,0.00001039101,0.000007784243,0.00003345371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007427393,0.00009627609,0.04159568,0.00006126425,0.00005612474,0.0337277,0.0003492238,0.0003675266,0.9068807,0.0003676998,0.0002435231,0.01551162],"study_design_scores_gemma":[0.0001324132,0.002175716,0.3307473,0.00003284102,0.00015543,0.2377224,0.0004832396,0.002914691,0.418558,0.0005299565,0.006505941,0.00004203637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992979,0.0001799616,0.0001801357,0.00002012176,0.000003401533,0.000003552497,0.00004604559,0.000009791171,0.0002590026],"genre_scores_gemma":[0.9995568,0.00006808082,0.00008650153,0.00001510399,0.000002492543,0.000002457183,0.00005747705,0.000003114012,0.0002079519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001140126,"threshold_uncertainty_score":0.003814101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009259399826053023,"score_gpt":0.2442315577334265,"score_spread":0.2349721579073735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}