{"id":"W4280584397","doi":"10.1126/science.abm6380","title":"Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin","year":2022,"lang":"en","type":"article","venue":"Science","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Biotech; National Cancer Institute; National Institutes of Health; Honjo International Scholarship Foundation; European Molecular Biology Organization; Fondation pour la Recherche Médicale; Memorial Sloan-Kettering Cancer Center; Institut National de la Santé et de la Recherche Médicale; European Commission; York University; Lastentautien Tutkimussäätiö; Institut des maladies génétiques Imagine; Cystic Fibrosis Foundation; KU Leuven; St. Giles Foundation; National Center for Advancing Translational Sciences; Fondation Bettencourt Schueller; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Agence Nationale de la Recherche; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute","keywords":"Haploinsufficiency; Biology; Immunology; Staphylococcus aureus; Tumor necrosis factor alpha; Toxin; Microbiology; Gene; Genetics; Phenotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001929497,0.000245997,0.0002717543,0.0005138377,0.005069889,0.00006617022,0.002107067,0.00006590007,0.00212861],"category_scores_gemma":[0.0001137397,0.0002463482,0.0001318041,0.002301158,0.001249916,0.0002249008,0.001310671,0.00078336,0.0009005623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002147801,"about_ca_system_score_gemma":0.0004602371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000372985,"about_ca_topic_score_gemma":0.00000578669,"domain_scores_codex":[0.9973274,0.0002659082,0.0004241719,0.0006767003,0.0002364846,0.001069356],"domain_scores_gemma":[0.9988544,0.000051067,0.0001316734,0.0008260507,0.0001043549,0.00003244233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003516085,0.0006633258,0.0003500802,0.00000593662,0.000006405916,0.000004492716,0.003122668,0.0007376022,0.9873692,0.001503573,0.0003279703,0.00587353],"study_design_scores_gemma":[0.0043886,0.004325185,0.2023045,0.00003634386,0.00005235644,0.0001542507,0.03799421,0.000108322,0.4296421,0.001336465,0.3174199,0.002237748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860082,0.004063763,0.0001216865,0.0002531543,0.001319708,0.0004218501,0.00003714014,0.000172587,0.00760186],"genre_scores_gemma":[0.9963492,0.000005213653,0.00003406478,0.000524841,0.000003649704,0.00008299937,0.00002184988,0.00001697673,0.002961226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5577271,"threshold_uncertainty_score":0.9999989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009259399826053023,"score_gpt":0.2442315577334265,"score_spread":0.2349721579073735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}