{"id":"W4280584569","doi":"10.1136/jnnp-2022-329024","title":"Effect of sodium phenylbutyrate/taurursodiol on tracheostomy/ventilation-free survival and hospitalisation in amyotrophic lateral sclerosis: long-term results from the CENTAUR trial","year":2022,"lang":"en","type":"article","venue":"Journal of Neurology Neurosurgery & Psychiatry","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Robert Packard Center for ALS Research, Johns Hopkins University; National Center for Advancing Translational Sciences; National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; Cytokinetics; Acorda Therapeutics; Sanofi Genzyme; Rare Diseases Clinical Research Network; Weill Cornell Medical College; CSL Behring; Northeast Amytrophic Lateral Sclerosis Consortium; Ionis Pharmaceuticals; Sarepta Therapeutics; Target ALS; National Institutes of Health; Regeneron Pharmaceuticals; Apellis Pharmaceuticals; Alexion Pharmaceuticals; ALS Hope Foundation; American Academy of Neurology; AstraZeneca; Congressionally Directed Medical Research Programs; Disarm Therapeutics; U.S. Department of Defense; Sanofi; Muscular Dystrophy Association; Hope Foundation; UCB Pharma; Argenx; ALS Association; Chan Zuckerberg Initiative; York University; Biogen; GlaxoSmithKline; Alnylam Pharmaceuticals","keywords":"Amyotrophic lateral sclerosis; Medicine; Phenylbutyrate; Randomized controlled trial; Internal medicine; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002720201,0.0003307401,0.0009243205,0.0004228994,0.0002202483,0.00004599231,0.0004979029,0.0001562376,0.00009244962],"category_scores_gemma":[0.000776673,0.000236562,0.0004129722,0.0004713871,0.0002444976,0.0002004801,0.0002210675,0.001945766,0.000002413183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000673774,"about_ca_system_score_gemma":0.0002092589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005396116,"about_ca_topic_score_gemma":0.00001742645,"domain_scores_codex":[0.9934094,0.002817965,0.0015783,0.0005262103,0.001198508,0.0004696428],"domain_scores_gemma":[0.9959794,0.001914483,0.001154196,0.0006574448,0.0001076056,0.0001869111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2804659,0.0009971652,0.70403,0.0000399916,0.000125003,0.0003138818,0.0001873296,0.0001970006,0.009536795,0.00001632838,0.00298747,0.001103135],"study_design_scores_gemma":[0.04530952,0.01312763,0.9405092,0.0001105599,0.0001253283,0.0001896752,0.00001456632,0.00009652835,0.0002060046,0.00009418077,0.00007545099,0.0001413328],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9612966,0.0003281343,0.000001657582,0.0315198,0.005875603,0.0008296774,0.0001099501,0.00001795538,0.00002058478],"genre_scores_gemma":[0.9964986,0.0002883961,0.00001039381,0.002226183,0.0008342382,0.00003080983,0.00003801661,0.00005353,0.00001980798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2364793,"threshold_uncertainty_score":0.9646719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02512018418641393,"score_gpt":0.2785672208184976,"score_spread":0.2534470366320836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}