{"id":"W4280584583","doi":"10.1182/bloodadvances.2022007450","title":"Treatment of an HLH-mimic disease based on <i>HAVCR2</i> variants with absent TIM-3 expression","year":2022,"lang":"en","type":"article","venue":"Blood Advances","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Universiteit van Amsterdam; Amsterdam University Medical Centers","keywords":"Expression (computer science); Disease; Biology; Immunology; Computational biology; Medicine; Pathology; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006953095,0.0001473333,0.0002704562,0.0001054204,0.0001779807,0.000006795597,0.0001022091,0.0000170088,0.0003958066],"category_scores_gemma":[0.00001537467,0.0001011425,0.00006572483,0.0001564468,0.00006840096,0.0001145641,0.00002823664,0.00009326301,0.00000691857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004405385,"about_ca_system_score_gemma":0.0002659437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001336564,"about_ca_topic_score_gemma":0.000002071659,"domain_scores_codex":[0.9986636,0.00008762321,0.0002007333,0.0002828811,0.000550483,0.0002146914],"domain_scores_gemma":[0.9992144,0.00004256895,0.00009835696,0.0004520943,0.00003859253,0.0001540058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05801229,0.07864223,0.2998299,0.001790324,0.0006751694,0.006614329,0.002509798,0.05342573,0.2319478,0.0007421933,0.0008638175,0.2649465],"study_design_scores_gemma":[0.07556593,0.08324412,0.3003789,0.001117355,0.001250777,0.000153584,0.005190788,0.02147046,0.2655837,0.0004586165,0.2439694,0.001616501],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929871,0.002979632,0.00004645337,0.0004435407,0.00005344799,0.0006772261,0.00006119976,0.00005520597,0.00269622],"genre_scores_gemma":[0.9980707,0.0001821498,0.0004701428,0.0001660163,0.00003465494,0.0002248606,0.0001086291,0.00002494171,0.0007179573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.26333,"threshold_uncertainty_score":0.4333805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01255554605508305,"score_gpt":0.280896710250797,"score_spread":0.268341164195714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}