{"id":"W4280584858","doi":"10.3390/pharmaceutics14051063","title":"Comparison of the Effects of Three Dual-Nucleos(t)ide Reverse Transcriptase Inhibitor Backbones on Placenta Mitochondria Toxicity and Oxidative Stress Using a Mouse Pregnancy Model","year":2022,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"HIV-related health complications and treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Saskatchewan Health; University of Toronto; University Health Network; University of Saskatchewan; Saskatchewan Health Authority","funders":"Canadian Institutes of Health Research","keywords":"Lamivudine; Emtricitabine; Zidovudine; Abacavir; Mitochondrial toxicity; Oxidative stress; Efavirenz; Reverse-transcriptase inhibitor; Transplacental; Placenta; Biology; Pharmacology; Mitochondrion; Endocrinology; Reverse transcriptase; Biochemistry; Fetus; Virology; Pregnancy; Viral load","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005215739,0.0006458582,0.0006568951,0.0007654965,0.0002065729,0.0004713651,0.0004778313,0.000634324,0.001197282],"category_scores_gemma":[0.0003063984,0.0004132356,0.0007363359,0.0003482025,0.0004647109,0.0005506174,0.0002515072,0.001480194,0.0002003255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004517589,"about_ca_system_score_gemma":0.0003777846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001046216,"about_ca_topic_score_gemma":0.001272945,"domain_scores_codex":[0.9995597,0.00008922184,0.00005328087,0.0001089681,0.0001007741,0.00008803752],"domain_scores_gemma":[0.9995803,0.00007505275,0.0001289555,0.00004629138,0.00005107372,0.0001182976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004179882,0.0008491823,0.0004926478,0.0001998251,0.00005188772,0.0001557905,0.00005834461,0.0002218952,0.989221,0.0002023173,0.0001296422,0.00423761],"study_design_scores_gemma":[0.0003281489,0.01790048,0.004257458,0.00003786472,0.0002606695,0.0003233188,0.0001117076,0.001372553,0.9720614,0.0001844414,0.003137785,0.00002410356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856308,0.006290326,0.003858234,0.0003997673,0.0001760616,0.0002122851,0.001097696,0.0001623263,0.002172585],"genre_scores_gemma":[0.9811909,0.006491144,0.00580727,0.0002610313,0.00004352363,0.0004311434,0.001152513,0.00005867277,0.004563779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001197282,"threshold_uncertainty_score":0.004005313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0862980693640743,"score_gpt":0.3867017976944352,"score_spread":0.3004037283303609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}