{"id":"W4280584858","doi":"10.3390/pharmaceutics14051063","title":"Comparison of the Effects of Three Dual-Nucleos(t)ide Reverse Transcriptase Inhibitor Backbones on Placenta Mitochondria Toxicity and Oxidative Stress Using a Mouse Pregnancy Model","year":2022,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"HIV-related health complications and treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Saskatchewan Health; University of Toronto; University Health Network; University of Saskatchewan; Saskatchewan Health Authority","funders":"Canadian Institutes of Health Research","keywords":"Lamivudine; Emtricitabine; Zidovudine; Abacavir; Mitochondrial toxicity; Oxidative stress; Efavirenz; Reverse-transcriptase inhibitor; Transplacental; Placenta; Biology; Pharmacology; Mitochondrion; Endocrinology; Reverse transcriptase; Biochemistry; Fetus; Virology; Pregnancy; Viral load","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006647235,0.0001615242,0.0003460678,0.00009854639,0.0002547945,0.000004077942,0.00008839252,0.00004693334,0.000025184],"category_scores_gemma":[0.00003686871,0.000129813,0.00008157116,0.0002696402,0.0001009102,0.00004694049,0.00009048096,0.0003508019,8.878517e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001391101,"about_ca_system_score_gemma":0.0001087802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004601155,"about_ca_topic_score_gemma":0.000009662117,"domain_scores_codex":[0.998748,0.0001293718,0.0003788711,0.0002254294,0.0003253284,0.0001929926],"domain_scores_gemma":[0.9990903,0.0001399429,0.0002496007,0.0003275737,0.00007229846,0.0001203375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001727316,0.009266272,0.1216029,0.003151215,0.000612491,0.00002749244,0.009496653,0.01394225,0.8360096,0.0006162735,0.001004472,0.002543074],"study_design_scores_gemma":[0.009549662,0.0008320312,0.002571897,0.001486138,0.001175387,0.00001749963,0.0006088438,0.2891074,0.6939864,0.00009829237,0.0003577065,0.0002088264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958337,0.001478691,0.0001978692,0.0002940136,0.0001846294,0.001486185,0.0004126727,0.00001904222,0.00009321087],"genre_scores_gemma":[0.9984013,0.000136333,0.001051999,0.0001537034,0.00001446546,0.00005281858,0.00002338876,0.00002363496,0.0001423841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2751651,"threshold_uncertainty_score":0.5293619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0862980693640743,"score_gpt":0.3867017976944352,"score_spread":0.3004037283303609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}