{"id":"W4280586660","doi":"10.3389/fphar.2022.876842","title":"Treatment With LAU-7b Complements CFTR Modulator Therapy by Improving Lung Physiology and Normalizing Lipid Imbalance Associated With CF Lung Disease","year":2022,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Erasmus Medisch Centrum; McGill University Health Centre; Cystic Fibrosis Canada; Ministère du Développement Économique, de l’Innovation et de l’Exportation","keywords":"Cystic fibrosis; Ivacaftor; Lung; Medicine; Pharmacology; Combination therapy; Endoplasmic reticulum; Bioinformatics; Cystic fibrosis transmembrane conductance regulator; Internal medicine; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001905924,0.000399662,0.0008968714,0.0005219317,0.000255972,0.0002777986,0.0003044255,0.0006065334,0.002002038],"category_scores_gemma":[0.0001293174,0.0001192672,0.0005024586,0.0001691843,0.0002921483,0.0002698823,0.000265181,0.00107267,0.000475478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001769777,"about_ca_system_score_gemma":0.0002688025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005283001,"about_ca_topic_score_gemma":0.001403002,"domain_scores_codex":[0.9998186,0.00003288798,0.00001724511,0.00002860542,0.00005854318,0.00004413133],"domain_scores_gemma":[0.9998677,0.00001449267,0.00002742442,0.0000102666,0.00001966435,0.00006049449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003069826,0.001086313,0.001073627,0.0002124099,0.00004234853,0.0002780773,0.00003799197,0.0001731524,0.9703934,0.00007779495,0.0002812777,0.02327381],"study_design_scores_gemma":[0.0007996393,0.06296042,0.02971992,0.0001342685,0.0003049325,0.002292207,0.0002149275,0.001866478,0.8865525,0.0002071101,0.01490286,0.00004478694],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862053,0.008886306,0.001751687,0.0004302709,0.0001525912,0.000163326,0.0004024966,0.0002309171,0.001777093],"genre_scores_gemma":[0.9864843,0.004979555,0.003816874,0.0003821503,0.00007492875,0.0001762024,0.00078704,0.00004005709,0.00325884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002002038,"threshold_uncertainty_score":0.006697476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008814106786783602,"score_gpt":0.2921940607480767,"score_spread":0.2833799539612931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}