{"id":"W4280589085","doi":"10.1093/genetics/iyac075","title":"Translational suppression via IFG-1/eIF4G inhibits stress-induced RNA alternative splicing in <i>Caenorhabditis elegans</i>","year":2022,"lang":"en","type":"article","venue":"Genetics","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Tokyo Medical and Dental University; Saskatchewan Health Research Foundation; East Carolina University; University of Minnesota","keywords":"Biology; RNA splicing; EIF4G; Genetics; Splicing factor; Spliceosome; Cell biology; Alternative splicing; Caenorhabditis elegans; RNA; Translation (biology); Gene; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001427587,0.0004883673,0.0002855234,0.0002186028,0.0001824691,0.0002653922,0.0003513366,0.0002583577,0.0006600067],"category_scores_gemma":[0.0001057796,0.0001658344,0.0002651393,0.0001049744,0.0002485439,0.0001056815,0.000166696,0.0004631946,0.0002684232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004751126,"about_ca_system_score_gemma":0.0003044522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001904949,"about_ca_topic_score_gemma":0.003788523,"domain_scores_codex":[0.9998842,0.00001025954,0.00001408205,0.00003556849,0.00003154254,0.00002426011],"domain_scores_gemma":[0.9998986,0.00001563933,0.00003891669,0.00001137213,0.000009407721,0.00002618582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004280581,0.00001519451,0.0001063873,0.00001892022,0.000002659475,0.00002229269,0.000003947047,0.00005029175,0.9991177,0.00003184959,0.00003788177,0.0005502278],"study_design_scores_gemma":[0.00001813025,0.0001292039,0.003654192,0.000005642007,0.00001336469,0.00006817392,0.00001033446,0.001262815,0.9929281,0.00002587886,0.001879031,0.000005122942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994695,0.0009038455,0.002045269,0.0001310114,0.00004620135,0.00002857774,0.0005243933,0.0002180572,0.001407638],"genre_scores_gemma":[0.9909725,0.000707243,0.004377947,0.0001224689,0.00001379336,0.00005125597,0.0009225878,0.0000969283,0.002735205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001904949,"threshold_uncertainty_score":0.003787756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01307867157495707,"score_gpt":0.2680143175359089,"score_spread":0.2549356459609518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}