{"id":"W4280589085","doi":"10.1093/genetics/iyac075","title":"Translational suppression via IFG-1/eIF4G inhibits stress-induced RNA alternative splicing in <i>Caenorhabditis elegans</i>","year":2022,"lang":"en","type":"article","venue":"Genetics","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Tokyo Medical and Dental University; Saskatchewan Health Research Foundation; East Carolina University; University of Minnesota","keywords":"Biology; RNA splicing; EIF4G; Genetics; Splicing factor; Spliceosome; Cell biology; Alternative splicing; Caenorhabditis elegans; RNA; Translation (biology); Gene; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002289163,0.0001761555,0.0001554423,0.0001188872,0.000217922,0.00002844005,0.000314485,0.00008644976,0.0001092118],"category_scores_gemma":[0.00002625001,0.0001944276,0.00007711241,0.0002079447,0.00003668281,0.000006160258,0.0002549314,0.0003180905,0.000005489579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004111938,"about_ca_system_score_gemma":0.0001200159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001279596,"about_ca_topic_score_gemma":0.0002837874,"domain_scores_codex":[0.998222,0.0001613846,0.0002889153,0.0004359335,0.0004521338,0.0004396459],"domain_scores_gemma":[0.9994211,0.00002340219,0.00007752386,0.000292647,0.00006282369,0.0001224913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008019913,0.00008743077,0.004704466,0.0000122492,0.00002265348,0.00003114511,0.0001743536,0.007093772,0.97838,0.0000211048,0.0004490094,0.008943592],"study_design_scores_gemma":[0.001152433,0.0003730715,0.005595805,0.00002033445,0.000007184893,0.0000262393,0.000178366,0.004462632,0.9834694,0.0001707925,0.00427695,0.0002667815],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964951,0.0005810038,0.001532777,0.000250792,0.0001738781,0.0002875444,0.0001281748,0.00001064635,0.0005401181],"genre_scores_gemma":[0.9978877,0.0001334559,0.0005788609,0.0002176918,0.0002473104,0.0000625746,0.0003396926,0.00003577624,0.0004969923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008676811,"threshold_uncertainty_score":0.7928527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01307867157495707,"score_gpt":0.2680143175359089,"score_spread":0.2549356459609518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}