{"id":"W4280592992","doi":"10.1093/rheumatology/keac300","title":"Biological and clinical insights from a randomized phase 2 study of an anti-oncostatin M monoclonal antibody in systemic sclerosis","year":2022,"lang":"en","type":"article","venue":"Lara D. Veeken","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"GlaxoSmithKline (Canada); Toronto Western Hospital; University of Toronto; Mount Sinai Hospital","funders":"National Institute for Health and Care Research; GlaxoSmithKline","keywords":"Medicine; Placebo; Tolerability; Clinical endpoint; Internal medicine; Adverse effect; Randomized controlled trial; Cohort; Clinical trial; Gastroenterology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003366507,0.001043857,0.001695653,0.0003580859,0.0003413494,0.0008858631,0.0005479155,0.001708323,0.006556716],"category_scores_gemma":[0.002276046,0.0004449565,0.001316051,0.0003211266,0.0008193604,0.0006911567,0.0003353121,0.001836356,0.0006717162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004543131,"about_ca_system_score_gemma":0.001376947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003079385,"about_ca_topic_score_gemma":0.001100737,"domain_scores_codex":[0.9989665,0.0006098579,0.00007606667,0.0001034565,0.000110771,0.0001333363],"domain_scores_gemma":[0.9986101,0.0004721994,0.0003307612,0.0001143453,0.0001245424,0.0003480728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9332022,0.01218016,0.001611041,0.0008154871,0.00119412,0.0001553822,0.00008098797,0.0005076113,0.01994314,0.0001861392,0.001381481,0.02874221],"study_design_scores_gemma":[0.805095,0.1872288,0.003938195,0.0000374451,0.0007569603,0.0001014921,0.00002101802,0.0002597721,0.001210539,0.000143153,0.001190507,0.00001707623],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844413,0.004051349,0.001043152,0.0009357627,0.00033423,0.005917119,0.001298126,0.00007411997,0.001904882],"genre_scores_gemma":[0.9838164,0.002269954,0.002198138,0.001374582,0.0004173723,0.006238056,0.001536661,0.00002014718,0.00212864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006556716,"threshold_uncertainty_score":0.02193439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05882782610824001,"score_gpt":0.3536563620890277,"score_spread":0.2948285359807877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}