{"id":"W4280593482","doi":"10.51731/cjht.2022.330","title":"An Overview of New and Emerging Technologies for Early Diagnosis of Alzheimer Disease","year":2022,"lang":"en","type":"article","venue":"Canadian Journal of Health Technologies","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Disease; Biomarker; Medicine; Cognitive decline; Amyloid beta; Amyloid (mycology); Alzheimer's disease; Bioinformatics; Neuroscience; Pathology; Dementia; Psychology; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002410494,0.0001175256,0.0004802466,0.0006840529,0.0001729612,0.000008035382,0.0002031511,0.0000438235,0.00001757071],"category_scores_gemma":[0.0004950577,0.0001030758,0.0001108989,0.0003295254,0.0001849226,0.0001051337,0.00003877662,0.000209483,6.414504e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006112395,"about_ca_system_score_gemma":0.001894041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001190451,"about_ca_topic_score_gemma":0.0002432674,"domain_scores_codex":[0.9988649,0.00004125848,0.0005450508,0.0001477537,0.0001552399,0.000245723],"domain_scores_gemma":[0.99889,0.00005916887,0.0004660042,0.0002699663,0.0001588,0.0001559944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0002534438,0.0001713715,0.3524861,0.0007323156,0.000170569,0.0001457551,0.0006599167,0.00005744674,0.0005417952,0.00137354,0.005252765,0.6381549],"study_design_scores_gemma":[0.006980669,0.0147237,0.7238184,0.002615731,0.001496568,0.0004226447,0.03416158,0.0001452619,0.06784462,0.01674124,0.1301861,0.0008635676],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7039916,0.2808371,0.00002248082,0.0145878,0.00006949387,0.0002983725,0.0001538766,0.00003783974,0.00000139547],"genre_scores_gemma":[0.9939973,0.005153171,0.0004664828,0.0003109198,0.00000919366,0.00003543097,0.000006926565,0.00001538116,0.00000524636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6372914,"threshold_uncertainty_score":0.4203309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1187735335556829,"score_gpt":0.3797878448533067,"score_spread":0.2610143112976238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}