{"id":"W4280593482","doi":"10.51731/cjht.2022.330","title":"An Overview of New and Emerging Technologies for Early Diagnosis of Alzheimer Disease","year":2022,"lang":"en","type":"article","venue":"Canadian Journal of Health Technologies","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Disease; Biomarker; Medicine; Cognitive decline; Amyloid beta; Amyloid (mycology); Alzheimer's disease; Bioinformatics; Neuroscience; Pathology; Dementia; Psychology; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003780581,0.001506838,0.001262623,0.006642264,0.0008814226,0.002644588,0.002063881,0.002518769,0.009396047],"category_scores_gemma":[0.003978253,0.0006382485,0.00141578,0.003975063,0.0009645498,0.002940613,0.00128589,0.003113716,0.004904379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003661681,"about_ca_system_score_gemma":0.004812832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01607611,"about_ca_topic_score_gemma":0.02252798,"domain_scores_codex":[0.9977579,0.0003446187,0.000195795,0.0002314345,0.001275876,0.0001944559],"domain_scores_gemma":[0.9964567,0.001179367,0.0002047531,0.000108986,0.001793019,0.0002571649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001841995,0.0001683713,0.001122054,0.008057478,0.00009919595,0.0004592985,0.0001094153,0.0004045769,0.005098448,0.008131194,0.06400576,0.91216],"study_design_scores_gemma":[0.00002742156,0.0002356244,0.00214842,0.003865945,0.0001310026,0.002184746,0.0001242505,0.0006662653,0.002772861,0.004264833,0.9835008,0.00007776184],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007452947,0.968834,0.006510327,0.005573128,0.001559821,0.0001383113,0.0002294447,0.0002655799,0.016144],"genre_scores_gemma":[0.003695012,0.9729725,0.01355266,0.00238698,0.001347479,0.0001236576,0.0004000908,0.00003783409,0.005483769],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01607611,"threshold_uncertainty_score":0.03196508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1187735335556829,"score_gpt":0.3797878448533067,"score_spread":0.2610143112976238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}