{"id":"W4280595184","doi":"10.1016/s2213-8587(22)00135-8","title":"Osilodrostat for the treatment of Cushing's disease: efficacy, stability, and persistence – Authors' reply","year":2022,"lang":"en","type":"letter","venue":"The Lancet Diabetes & Endocrinology","topic":"Pituitary Gland Disorders and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"U.S. Food and Drug Administration","keywords":"Medicine; Persistence (discontinuity); Cushing's disease; Intensive care medicine; Disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004355625,0.0006355994,0.002187773,0.0008250016,0.00200471,0.002549722,0.001599269,0.04058045,0.003428476],"category_scores_gemma":[0.02600054,0.0006973443,0.001526163,0.0007588237,0.002329248,0.003113675,0.00111284,0.03801735,0.00287925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002980948,"about_ca_system_score_gemma":0.00243234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004094983,"about_ca_topic_score_gemma":0.00624872,"domain_scores_codex":[0.9966949,0.001119128,0.0006122043,0.0003827182,0.0008795297,0.0003114649],"domain_scores_gemma":[0.9844715,0.01148092,0.0009161429,0.0003533582,0.001792991,0.0009851001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003107384,0.00004617943,0.0007448289,0.0001197823,0.00006053464,0.001292263,0.0001208679,0.00005503354,0.0001667762,0.001394815,0.9850429,0.01064532],"study_design_scores_gemma":[0.0008878051,0.0002749864,0.003599702,0.0006133448,0.0001927908,0.002693702,0.0004891065,0.0005289488,0.0005139339,0.007758398,0.9822521,0.0001950928],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0003730332,0.003081782,0.00004630804,0.9646936,0.03095704,0.000007657521,0.0000802651,0.00001537411,0.0007448536],"genre_scores_gemma":[0.003051168,0.001439752,0.00009489095,0.935565,0.05777388,0.00002696856,0.00003282557,0.00001510069,0.00200048],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.04058045,"threshold_uncertainty_score":0.02303499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06136103035449662,"score_gpt":0.2945809546893923,"score_spread":0.2332199243348956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}