{"id":"W4280599473","doi":"10.1101/2022.05.19.492599","title":"Targeting Nup358/RanBP2 by a viral protein disrupts stress granule formation","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Science and Engineering Research Board; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; Génome Québec","keywords":"Stress granule; Biology; Cell biology; Ubiquitin ligase; RNA; Ribonucleoprotein; RNA-binding protein; RNA interference; Virology; Ubiquitin; Translation (biology); Messenger RNA; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001095718,0.0003000117,0.00019206,0.000138788,0.0001726354,0.0002407039,0.0002870004,0.0002722262,0.0008963157],"category_scores_gemma":[0.00005873784,0.000153875,0.0002379833,0.00009949075,0.0002364014,0.0001338137,0.0002058527,0.0004767699,0.0003231218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000409751,"about_ca_system_score_gemma":0.0001733435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001067801,"about_ca_topic_score_gemma":0.001245453,"domain_scores_codex":[0.999869,0.00001602253,0.00001559644,0.00003443473,0.00003627375,0.00002863735],"domain_scores_gemma":[0.999899,0.00001313282,0.00003402439,0.00001222899,0.000007376325,0.00003426231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003209631,0.000006931213,0.0000267764,0.000009941372,0.000001575977,0.00001378397,0.000003298966,0.00002075409,0.9997359,0.0000299237,0.00001184668,0.0001071623],"study_design_scores_gemma":[0.000006591476,0.00009040097,0.001857996,0.000002782321,0.000004641407,0.00007175407,0.00001091899,0.001041349,0.9960691,0.00001831837,0.0008232327,0.000002960822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956654,0.0006644193,0.002084921,0.00005849871,0.00003058894,0.00002527055,0.0005087266,0.0001266517,0.0008355195],"genre_scores_gemma":[0.9958547,0.0002015985,0.001675059,0.00002976606,0.000004174216,0.00002425106,0.0004114799,0.00002549072,0.001773472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001067801,"threshold_uncertainty_score":0.002998412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007670845744633842,"score_gpt":0.2317089157204926,"score_spread":0.2240380699758588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}