{"id":"W4280605905","doi":"10.1016/j.eururo.2022.04.022","title":"Can Oncogenic Driver Alterations be Responsible for the Lack of Immunotherapy Efficacy in First-line Advanced Urothelial Carcinoma?","year":2022,"lang":"en","type":"editorial","venue":"European Urology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Kingston Health Sciences Centre; Queen's University","funders":"","keywords":"Medicine; Biomarker; Immunotherapy; Urothelial carcinoma; Cancer research; First line; Carcinoma; Oncology; Internal medicine; Cancer; Bladder cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005889309,0.0003926192,0.0007445142,0.0002590792,0.0002282401,0.000013855,0.0004703107,0.0001998875,0.0006734611],"category_scores_gemma":[0.0006167027,0.0003093539,0.0003331801,0.0002599132,0.0001932471,0.00002925377,0.0001405155,0.000870971,0.00001576259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002217538,"about_ca_system_score_gemma":0.001156397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003373274,"about_ca_topic_score_gemma":0.000583219,"domain_scores_codex":[0.9972618,0.0005849417,0.0006853214,0.0006176797,0.0004091802,0.0004410498],"domain_scores_gemma":[0.9963766,0.002166584,0.0003060673,0.0008921875,0.0001789979,0.00007951334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02988879,0.001507747,0.0006019111,0.0001779306,0.001108629,0.0003809712,0.003870335,0.001630605,0.003336644,0.0001601573,0.9479483,0.009388017],"study_design_scores_gemma":[0.01542006,0.004421416,0.002681808,0.00002683866,0.0003932778,0.00001436986,0.00003012825,0.00003955206,0.0002578769,0.00004012406,0.9764524,0.0002221983],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.05594181,0.01459907,0.0002813515,0.02438967,0.879835,0.01003046,0.008014766,0.000220998,0.006686866],"genre_scores_gemma":[0.4241447,0.005735525,0.0005660911,0.005418948,0.5413085,0.00114843,0.004007743,0.0008205488,0.01684951],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.3682029,"threshold_uncertainty_score":0.9999359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03441785734394094,"score_gpt":0.3247581035764824,"score_spread":0.2903402462325415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}