{"id":"W4280608996","doi":"10.1172/jci148333","title":"HDAC6 modulates myofibril stiffness and diastolic function of the heart","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Heart, Lung, and Blood Institute; National Institute on Aging; American Heart Association; Canadian Institutes of Health Research; Anschutz Medical Campus, University of Colorado; National Center for Advancing Translational Sciences; Italfarmaco; Small Business Innovation Research; Novo Nordisk; National Institutes of Health; Eikonizo Therapeutics; Novo Nordisk Fonden; Boettcher Foundation","keywords":"Titin; Myofibril; Sarcomere; HDAC6; Obscurin; Diastole; Internal medicine; Cardiomyopathy; Myofilament; Myocyte; Chemistry; Histone deacetylase; Cell biology; Heart failure; Medicine; Biology; Biochemistry; Histone","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001278423,0.00005765574,0.0001737352,0.00004206894,0.0001081829,0.000008698429,0.0001249188,0.00006681508,0.00001445942],"category_scores_gemma":[0.001022515,0.00004342919,0.0001391157,0.000125288,0.0002553875,0.00000777027,0.0001422444,0.0002833871,6.278472e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001377201,"about_ca_system_score_gemma":0.0002170675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009038857,"about_ca_topic_score_gemma":0.000003353728,"domain_scores_codex":[0.9984112,0.0004422062,0.0006230177,0.0001134109,0.0003277681,0.00008238439],"domain_scores_gemma":[0.999039,0.00008964445,0.0004416966,0.0001589904,0.0001791326,0.00009154771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003668513,0.00008403767,0.03054258,0.00002334963,0.00005752489,0.000001167011,0.00007356815,0.001287276,0.9522613,0.00007819321,0.009573959,0.005650214],"study_design_scores_gemma":[0.001795156,0.00168435,0.6885794,0.00005290401,0.00007061232,0.0001379386,0.0001729086,0.0008214631,0.2579088,0.001818015,0.04679692,0.0001614767],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977424,0.0003499677,0.00005799888,0.001256601,0.0004731153,0.0000800133,0.000005111542,0.000001372119,0.0000334564],"genre_scores_gemma":[0.998988,0.00003313811,0.0001325997,0.0003013634,0.0003658708,0.000002830826,0.000005325975,0.000008422478,0.0001624815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6943525,"threshold_uncertainty_score":0.1770991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04543004352491622,"score_gpt":0.3469758737127926,"score_spread":0.3015458301878765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}