{"id":"W4280608996","doi":"10.1172/jci148333","title":"HDAC6 modulates myofibril stiffness and diastolic function of the heart","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Heart, Lung, and Blood Institute; National Institute on Aging; American Heart Association; Canadian Institutes of Health Research; Anschutz Medical Campus, University of Colorado; National Center for Advancing Translational Sciences; Italfarmaco; Small Business Innovation Research; Novo Nordisk; National Institutes of Health; Eikonizo Therapeutics; Novo Nordisk Fonden; Boettcher Foundation","keywords":"Titin; Myofibril; Sarcomere; HDAC6; Obscurin; Diastole; Internal medicine; Cardiomyopathy; Myofilament; Myocyte; Chemistry; Histone deacetylase; Cell biology; Heart failure; Medicine; Biology; Biochemistry; Histone","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001199848,0.0002455492,0.0001889345,0.0001306559,0.0001171263,0.0002620769,0.0001810029,0.0001750432,0.001235428],"category_scores_gemma":[0.00009384715,0.0001093879,0.0001879954,0.00009109588,0.0001764602,0.0001353142,0.0001144147,0.0003283031,0.0002844284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002232954,"about_ca_system_score_gemma":0.0001436108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004076906,"about_ca_topic_score_gemma":0.001435125,"domain_scores_codex":[0.9999294,0.00001039918,0.000007019762,0.00001530176,0.00001470272,0.00002316368],"domain_scores_gemma":[0.999956,0.000003752587,0.0000128678,0.000004451584,0.00000664998,0.00001623461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002986086,0.00003580435,0.0008186597,0.00004320522,0.00001274744,0.00002305417,0.000008852653,0.00003876139,0.9953768,0.00007715677,0.00009202656,0.003174281],"study_design_scores_gemma":[0.0001309147,0.0009105098,0.05181146,0.00001344206,0.00008591475,0.0003317425,0.00006138001,0.001254402,0.9390145,0.0001213607,0.006255214,0.000009053362],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871325,0.007494275,0.001603986,0.0002685721,0.0001003714,0.00002272646,0.0004170056,0.00008684761,0.00287377],"genre_scores_gemma":[0.9934896,0.002539244,0.0006583756,0.00006584599,0.00003158229,0.00001142672,0.0003094735,0.00001167093,0.002882804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001235428,"threshold_uncertainty_score":0.004132926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04543004352491622,"score_gpt":0.3469758737127926,"score_spread":0.3015458301878765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}