{"id":"W4280612854","doi":"10.3389/fnmol.2022.807202","title":"The Contribution of HCN Channelopathies in Different Epileptic Syndromes, Mechanisms, Modulators, and Potential Treatment Targets: A Systematic Review","year":2022,"lang":"en","type":"review","venue":"Frontiers in Molecular Neuroscience","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Natural Science Foundation of China","keywords":"Epilepsy; Channelopathy; Neuroscience; Phenotype; Postsynaptic potential; Medicine; Inhibitory postsynaptic potential; Epilepsy syndromes; Bioinformatics; Biology; Internal medicine; Genetics; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003552724,0.001234831,0.006412471,0.006108434,0.0003628231,0.001638463,0.001256322,0.001450484,0.003477239],"category_scores_gemma":[0.01500044,0.0006316764,0.00758806,0.006525478,0.000459154,0.0013409,0.0009749221,0.0008236642,0.0002678863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00160311,"about_ca_system_score_gemma":0.005475864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005898742,"about_ca_topic_score_gemma":0.01488737,"domain_scores_codex":[0.9976191,0.0006932681,0.0009497234,0.0002639715,0.0003622474,0.0001116315],"domain_scores_gemma":[0.9911719,0.006613211,0.001266579,0.0001188757,0.0007335581,0.00009600656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0002627656,0.00001319822,0.001087124,0.9258428,0.01346215,0.0001318472,0.0001005099,0.0001898565,0.0002405157,0.0003405986,0.002220692,0.05610797],"study_design_scores_gemma":[0.0003835387,0.000267931,0.00763794,0.7354835,0.2113993,0.0009528769,0.0002525575,0.0002369085,0.0003122019,0.0008342193,0.042179,0.00006005983],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004995324,0.9987893,0.00009063722,0.000146171,0.00006149841,0.00005515669,0.0002146935,0.000003937143,0.0001391201],"genre_scores_gemma":[0.007314708,0.9916764,0.0002573513,0.0003234203,0.00006235164,0.0001289174,0.0001719866,0.000002651553,0.00006211091],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006412471,"threshold_uncertainty_score":0.01878881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01221468333152211,"score_gpt":0.2492479120335995,"score_spread":0.2370332287020774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}