{"id":"W4280614341","doi":"10.1016/j.tibtech.2022.04.005","title":"Se(XY) matters: the importance of incorporating sex in microphysiological models","year":2022,"lang":"en","type":"review","venue":"Trends in biotechnology","topic":"Sex and Gender in Healthcare","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Preclinical research; Clinical trial; Sexual dimorphism; Biology; Government (linguistics); Animal testing; Basic research; Function (biology); Neuroscience; Bioinformatics; Computer science; Evolutionary biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005021478,0.0003485572,0.001927257,0.0009954087,0.00004433106,0.000003057039,0.0005460633,0.001115661,0.0002502462],"category_scores_gemma":[0.00004284988,0.0002267597,0.0002462681,0.001895008,0.0003241397,0.00001941225,0.0003848002,0.002198161,0.000004369778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002604728,"about_ca_system_score_gemma":0.000159689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001637801,"about_ca_topic_score_gemma":0.0001296005,"domain_scores_codex":[0.9973467,0.0002772927,0.001125094,0.0006766502,0.0001756261,0.0003986236],"domain_scores_gemma":[0.9982176,0.0002342825,0.000485575,0.001017314,0.00001197684,0.00003326309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001616348,0.00009746705,0.0002236907,0.003380245,0.00004063813,0.0001799135,0.000141565,0.000007633407,0.00001363908,0.001291477,0.0002230192,0.9943845],"study_design_scores_gemma":[0.0007018611,0.0006359625,0.0001467624,0.003205783,0.0001618611,0.0005604972,0.0009620143,0.0001718713,0.00004348016,0.004330227,0.9886156,0.0004640978],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001276288,0.99394,0.000005077392,0.003539005,0.0001410384,0.0004762713,0.0000448034,0.00008072229,0.0004967866],"genre_scores_gemma":[0.00236963,0.9956355,0.0005842604,0.0007214993,0.00005398914,0.0002365814,0.0002067562,0.0000423077,0.0001494837],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9939204,"threshold_uncertainty_score":0.9550038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2360266716185132,"score_gpt":0.4178885173317352,"score_spread":0.181861845713222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}