{"id":"W4280616571","doi":"10.21203/rs.3.rs-1523595/v2","title":"Efficacy and toxicity of combined inhibition of EGFR and VEGF in patients with advanced non-small-cell lung cancer harboring activating EGFR mutations: A systematic review and meta-analysis","year":2022,"lang":"en","type":"review","venue":"Research Square","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Amgen Canada; AstraZeneca; Eli Lilly and Company; Amgen","keywords":"Medicine; Oncology; Internal medicine; Hazard ratio; Meta-analysis; Lung cancer; Epidermal growth factor receptor; Clinical endpoint; Adverse effect; Cochrane Library; Randomized controlled trial; Confidence interval; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008872722,0.002547321,0.01755068,0.004491522,0.0004865697,0.002687569,0.00174754,0.001986217,0.00276127],"category_scores_gemma":[0.01682868,0.001346345,0.03483227,0.004890596,0.000577432,0.001351279,0.001033682,0.001455512,0.0002766681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002402385,"about_ca_system_score_gemma":0.002467035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00548618,"about_ca_topic_score_gemma":0.0126984,"domain_scores_codex":[0.9946136,0.002614651,0.001430715,0.000562372,0.0005998469,0.0001787716],"domain_scores_gemma":[0.9913889,0.005910457,0.001590765,0.0002541663,0.0007166298,0.0001391057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.002845859,0.00003043282,0.002205296,0.3240219,0.659682,0.0001110901,0.00006030153,0.0007235838,0.0003748346,0.00009080726,0.0004761555,0.009377704],"study_design_scores_gemma":[0.0005956126,0.0002264645,0.001940403,0.01502748,0.9807518,0.00007338096,0.00002519905,0.0001679194,0.0001217128,0.00009392883,0.0009598602,0.00001640718],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007655423,0.9905528,0.0004461065,0.0001497575,0.0001230939,0.0003040201,0.0004546218,0.00002652782,0.0002876182],"genre_scores_gemma":[0.2390198,0.7552545,0.00218364,0.0009005413,0.0002552262,0.001085328,0.0008301315,0.00003450674,0.0004362991],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01755068,"threshold_uncertainty_score":0.046924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07069963616731054,"score_gpt":0.4343506532759887,"score_spread":0.3636510171086781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}