{"id":"W4280628854","doi":"10.3389/fcell.2022.856243","title":"Peroxisomes Regulate Cellular Free Fatty Acids to Modulate Mast Cell TLR2, TLR4, and IgE-Mediated Activation","year":2022,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Health Authority; Dalhousie University","funders":"Canadian Institutes of Health Research; Dalhousie University; Natural Sciences and Engineering Research Council of Canada; Dalhousie Medical Research Foundation","keywords":"Cell biology; Biology; Peroxisome; Immune system; Degranulation; Chemokine; Cytokine; Mast cell; Receptor; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002453172,0.0002735243,0.0004007689,0.0003339092,0.0004114152,0.00001499365,0.000243354,0.0002282904,0.0005593176],"category_scores_gemma":[0.00001696868,0.0002679725,0.00003663124,0.0002416943,0.0002238152,0.0000649852,0.0006321928,0.0003453055,0.00003438478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001374659,"about_ca_system_score_gemma":0.00004764853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001215648,"about_ca_topic_score_gemma":0.00001806,"domain_scores_codex":[0.9983163,0.0001888826,0.0003656395,0.0005959988,0.00004448591,0.0004886702],"domain_scores_gemma":[0.9995753,0.00005246102,0.0001037888,0.0001818363,0.00002056677,0.00006600352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003817939,0.0001588835,0.06935026,0.0000443322,0.00004647284,0.00001251821,0.002023673,0.00001492128,0.9085141,0.00004627628,0.01407039,0.005336355],"study_design_scores_gemma":[0.006751002,0.000864205,0.0549767,0.00002094814,0.00003208446,0.00005361873,0.007088363,0.0001004282,0.4546259,0.001245576,0.4731394,0.001101741],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915372,0.002943306,0.000970128,0.0004222722,0.001087921,0.000378348,0.0001408576,0.0000438323,0.002476148],"genre_scores_gemma":[0.9880651,0.0002645751,0.004721257,0.0005925345,0.00001774065,0.00006703922,0.0007955717,0.00002305804,0.005453114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.459069,"threshold_uncertainty_score":0.9999772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005514453123868193,"score_gpt":0.1747735451360899,"score_spread":0.1692590920122217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}