{"id":"W4280628854","doi":"10.3389/fcell.2022.856243","title":"Peroxisomes Regulate Cellular Free Fatty Acids to Modulate Mast Cell TLR2, TLR4, and IgE-Mediated Activation","year":2022,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Health Authority; Dalhousie University","funders":"Canadian Institutes of Health Research; Dalhousie University; Natural Sciences and Engineering Research Council of Canada; Dalhousie Medical Research Foundation","keywords":"Cell biology; Biology; Peroxisome; Immune system; Degranulation; Chemokine; Cytokine; Mast cell; Receptor; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001864941,0.0004637542,0.0002625325,0.0004529147,0.0002403537,0.0003374368,0.0001819746,0.0004783946,0.002167231],"category_scores_gemma":[0.0001566029,0.0001471711,0.0005227876,0.0002009547,0.0002662491,0.0004467014,0.0005937594,0.0007044399,0.0006744582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003475732,"about_ca_system_score_gemma":0.0002002663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004215456,"about_ca_topic_score_gemma":0.0007078258,"domain_scores_codex":[0.9997528,0.0000412867,0.00002004897,0.00006140915,0.00005583726,0.00006860461],"domain_scores_gemma":[0.9998271,0.00001356935,0.00006181835,0.00001085927,0.00004040687,0.00004625051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002879212,0.00001677332,0.00057947,0.00009576631,0.0000131175,0.0001397125,0.00002371633,0.00004441235,0.9971209,0.0001595041,0.00009222141,0.001426567],"study_design_scores_gemma":[0.00006729428,0.0003526668,0.03455114,0.00007943161,0.00009888828,0.0008518535,0.0002489676,0.00106957,0.949794,0.0005624842,0.01229721,0.00002654014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9523,0.02582185,0.01356758,0.001213277,0.000319983,0.0001007895,0.001521342,0.0002505924,0.004904519],"genre_scores_gemma":[0.9820037,0.006196852,0.003792025,0.0003477772,0.00005881739,0.00007261185,0.0009932172,0.00004615085,0.006488865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002167231,"threshold_uncertainty_score":0.007250071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005514453123868193,"score_gpt":0.1747735451360899,"score_spread":0.1692590920122217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}