{"id":"W4280631056","doi":"10.1101/2022.05.11.491519","title":"A dynamic <i>in vitro</i> model of Down Syndrome neurogenesis with Trisomy 21 gene dosage correction","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institutes of Health; University of Connecticut","keywords":"XIST; Biology; Neurogenesis; Phenotype; Gene dosage; Transgene; Neural stem cell; Genetics; Gene silencing; Induced pluripotent stem cell; Gene; Cell biology; Embryonic stem cell; Stem cell; Gene expression; X-inactivation; X chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000143275,0.0003630027,0.0002296906,0.0002053982,0.0001961804,0.0003509357,0.0005244901,0.0003512326,0.002196024],"category_scores_gemma":[0.0000999305,0.0001812625,0.0002608548,0.0001408263,0.0003556698,0.000154564,0.0003767991,0.0007757975,0.0005284013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004308868,"about_ca_system_score_gemma":0.0002945634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002053832,"about_ca_topic_score_gemma":0.002222952,"domain_scores_codex":[0.9998574,0.00001714008,0.00001501298,0.0000379181,0.00005054862,0.00002195775],"domain_scores_gemma":[0.9998523,0.00002886734,0.00003892268,0.00003530268,0.00001134779,0.00003319909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005836006,0.00001880636,0.0001511822,0.00003568554,0.000004819198,0.0001375347,0.00001692943,0.0006555856,0.9971675,0.0006531371,0.000133657,0.0009667279],"study_design_scores_gemma":[0.00001540641,0.0001000204,0.0007980003,0.000006055534,0.00001127236,0.0002045052,0.00001957015,0.003353238,0.9919189,0.0001698126,0.003396787,0.000006500972],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9595501,0.001058239,0.02597404,0.000437715,0.0002833657,0.00008656189,0.00239755,0.000634569,0.009577927],"genre_scores_gemma":[0.9770175,0.0006468578,0.01151451,0.0001054527,0.00001787437,0.00009226092,0.0008168491,0.000159193,0.00962959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002196024,"threshold_uncertainty_score":0.007346392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006243648151045951,"score_gpt":0.1902993840666019,"score_spread":0.184055735915556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}