{"id":"W4280632528","doi":"10.1016/j.jogc.2022.02.068","title":"Multicentre Prospective Study of SNP-Based cfDNA Screening for Aneuploidy with Genetic Confirmation in 18 497 Pregnancies","year":2022,"lang":"en","type":"article","venue":"Journal of Obstetrics and Gynaecology Canada","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Medicine; Aneuploidy; Prospective cohort study; Single-nucleotide polymorphism; SNP; Cohort; Genetic testing; Oncology; Obstetrics; Gynecology; Genetics; Internal medicine; Genotype; Chromosome; Biology; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001613311,0.0008707797,0.001118746,0.0009220589,0.001750029,0.001357414,0.001175234,0.001363753,0.001712204],"category_scores_gemma":[0.008420436,0.001583886,0.0008378584,0.002103989,0.001007466,0.000693309,0.001011632,0.00133766,0.0005084598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001117863,"about_ca_system_score_gemma":0.00114389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03067962,"about_ca_topic_score_gemma":0.01784074,"domain_scores_codex":[0.9967771,0.001158978,0.0002103622,0.001025521,0.0004177688,0.000410305],"domain_scores_gemma":[0.9955461,0.001736365,0.001004937,0.0005164773,0.0004420081,0.0007541162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001285043,0.0002145366,0.9951669,0.00001333784,0.0001360852,0.001215042,0.000508477,0.00006797523,0.0003930591,0.00003610457,0.00007006915,0.0008934592],"study_design_scores_gemma":[0.0002102773,0.001002525,0.9963407,0.00001353408,0.0001551257,0.001146131,0.0005777435,0.0002704563,0.00007292387,0.00003522012,0.0001562144,0.00001928553],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993927,0.00010067,0.0000621692,0.00001810943,0.000005454274,0.00002090488,0.0001524291,0.000002041225,0.0002454653],"genre_scores_gemma":[0.999324,0.0000776963,0.000097768,0.00003834526,0.000008193379,0.00002766708,0.0002107164,0.0000050392,0.0002104445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03067962,"threshold_uncertainty_score":0.06100208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02072152485943385,"score_gpt":0.2492213964344898,"score_spread":0.2284998715750559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}