{"id":"W4280638650","doi":"10.1016/j.jtbi.2022.111160","title":"Modeling the influence of cell–cell contact and TGF-β signaling on the epithelial mesenchymal transition in MCF7 breast carcinoma cells","year":2022,"lang":"en","type":"article","venue":"Journal of Theoretical Biology","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"","keywords":"Epithelial–mesenchymal transition; Slug; Mesenchymal stem cell; Bistability; Cell biology; Cell; Cadherin; Biology; Contact inhibition; Cell adhesion; Cell migration; Chemistry; Downregulation and upregulation; Cancer research; Materials science; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002111736,0.0005277605,0.0006424051,0.0004187564,0.0004206047,0.0008441906,0.001115695,0.002155236,0.002932758],"category_scores_gemma":[0.0009549619,0.0004044365,0.0006844316,0.0005366046,0.0005018741,0.0004909739,0.0003911225,0.0005793751,0.0003090845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009544357,"about_ca_system_score_gemma":0.001115923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.04330977,"about_ca_topic_score_gemma":0.01509104,"domain_scores_codex":[0.9998502,0.00003037765,0.00000554826,0.00002381683,0.00003331811,0.000056657],"domain_scores_gemma":[0.9995286,0.0002904703,0.00005555229,0.00002011854,0.00007279071,0.00003249701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00004531786,0.00004575364,0.0008592568,0.00004637016,0.000011586,0.000110688,0.00003088244,0.9894454,0.005291366,0.003055644,0.0001392146,0.0009186267],"study_design_scores_gemma":[0.00000669942,0.00001709812,0.0002653785,0.000002843956,0.000006731929,0.000009990315,0.0000201421,0.9985103,0.0007111918,0.0002868969,0.000157984,0.000004698232],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9434875,0.0009332689,0.02483224,0.0005940722,0.00009557712,0.00003941692,0.0006016665,0.0001219267,0.02929432],"genre_scores_gemma":[0.994103,0.0003025513,0.0017083,0.00005883947,0.00001260748,0.00002495105,0.0001217424,0.0000212181,0.00364676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04330977,"threshold_uncertainty_score":0.08611536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00963300388577089,"score_gpt":0.2374491202733438,"score_spread":0.2278161163875729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}