{"id":"W4280640885","doi":"10.1016/j.jaapos.2022.03.005","title":"Aqueous humor as a surrogate biomarker for retinoblastoma tumor tissue","year":2022,"lang":"en","type":"article","venue":"Journal of American Association for Pediatric Ophthalmology and Strabismus","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Impact","funders":"","keywords":"Retinoblastoma; Germline; Loss of heterozygosity; Allele; Biology; Nonsense mutation; Genetics; Molecular biology; Compound heterozygosity; Exon; Germline mutation; Genotype; Mutation; Gene; Missense mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003384758,0.0008274021,0.0004273413,0.002925511,0.0006879682,0.002771347,0.000634934,0.001218595,0.001752506],"category_scores_gemma":[0.00541163,0.0003068796,0.0004677275,0.001543765,0.0009937831,0.001106237,0.0009421172,0.001023138,0.0006893724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008061366,"about_ca_system_score_gemma":0.001563793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00161333,"about_ca_topic_score_gemma":0.002100076,"domain_scores_codex":[0.9949713,0.001919025,0.0004466463,0.0006539767,0.001660951,0.0003481003],"domain_scores_gemma":[0.9963033,0.001187695,0.00117073,0.0003562567,0.0006984128,0.0002836834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004647176,0.0006219169,0.5549941,0.001548776,0.0008381011,0.002078751,0.0007732349,0.001358459,0.3102542,0.004619347,0.005990053,0.1122759],"study_design_scores_gemma":[0.0002752552,0.004604598,0.304576,0.0006660245,0.0008836325,0.01650074,0.002081078,0.0112883,0.6033589,0.004445827,0.05116608,0.0001536214],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8823879,0.05672914,0.03603866,0.001795244,0.00103299,0.0005109402,0.005516705,0.001092063,0.01489632],"genre_scores_gemma":[0.979296,0.00302806,0.01170626,0.0006802284,0.0001891892,0.0002513115,0.001674007,0.00005020358,0.003124659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003384758,"threshold_uncertainty_score":0.01790053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01483457325326019,"score_gpt":0.321014603867939,"score_spread":0.3061800306146788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}