{"id":"W4280641207","doi":"10.1007/s12035-022-02734-5","title":"SUMO1 Modification of Tau in Progressive Supranuclear Palsy","year":2022,"lang":"en","type":"article","venue":"Molecular Neurobiology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care; Nakayama Foundation for Human Science; Mitsui Sumitomo Insurance Welfare Foundation","keywords":"Progressive supranuclear palsy; SUMO protein; Tau protein; Chemistry; Phosphorylation; Cell biology; Protein aggregation; Immunoprecipitation; Fusion protein; Cytoplasm; Tauopathy; Ubiquitin; Proteasome; Biophysics; Biochemistry; Biology; Alzheimer's disease; Neurodegeneration; Atrophy; Medicine; Genetics; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001774691,0.0003305754,0.0002396147,0.0003575128,0.0003025944,0.0001991379,0.0001627744,0.0003208423,0.001152768],"category_scores_gemma":[0.0001078491,0.000142379,0.0002425791,0.0002539994,0.0003319476,0.0001717044,0.0002660966,0.0003689762,0.000370926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003603979,"about_ca_system_score_gemma":0.0002123548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001235423,"about_ca_topic_score_gemma":0.0019449,"domain_scores_codex":[0.9999216,0.00001326546,0.000007128469,0.00001510518,0.00002786156,0.00001495974],"domain_scores_gemma":[0.9999466,0.000006360384,0.00001783113,0.000005470688,0.000009152301,0.00001452759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002708507,0.00004291051,0.003895959,0.0001343653,0.00002870131,0.003196534,0.00009270482,0.0002634189,0.9867551,0.0003817725,0.0001947754,0.00474288],"study_design_scores_gemma":[0.00003308209,0.0005394212,0.1879124,0.0000528895,0.00009693066,0.01457372,0.0003495277,0.001094163,0.7874519,0.001114511,0.006763167,0.00001839674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932588,0.003460664,0.001262661,0.0001151145,0.00002323036,0.00001488009,0.0001526959,0.00003180276,0.001680227],"genre_scores_gemma":[0.9944113,0.002649133,0.0006066618,0.00006013391,0.000007673606,0.00001151523,0.0001793903,0.000006789444,0.002067434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001235423,"threshold_uncertainty_score":0.003856361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01347625874718418,"score_gpt":0.2502044465654631,"score_spread":0.2367281878182789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}