{"id":"W4280641207","doi":"10.1007/s12035-022-02734-5","title":"SUMO1 Modification of Tau in Progressive Supranuclear Palsy","year":2022,"lang":"en","type":"article","venue":"Molecular Neurobiology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care; Nakayama Foundation for Human Science; Mitsui Sumitomo Insurance Welfare Foundation","keywords":"Progressive supranuclear palsy; SUMO protein; Tau protein; Chemistry; Phosphorylation; Cell biology; Protein aggregation; Immunoprecipitation; Fusion protein; Cytoplasm; Tauopathy; Ubiquitin; Proteasome; Biophysics; Biochemistry; Biology; Alzheimer's disease; Neurodegeneration; Atrophy; Medicine; Genetics; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002186262,0.0001277645,0.00017395,0.00009063292,0.00005905958,0.000004219413,0.0002861696,0.00008732999,0.0001094106],"category_scores_gemma":[0.00006610522,0.0001401136,0.00008518819,0.0001656693,0.0001000189,0.000001700848,0.0002776715,0.0001729763,0.000006059661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001256806,"about_ca_system_score_gemma":0.00005687099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001678451,"about_ca_topic_score_gemma":0.000003862971,"domain_scores_codex":[0.9985838,0.0004460589,0.0002547884,0.0003831131,0.00008720039,0.0002450167],"domain_scores_gemma":[0.9994145,0.00001157314,0.0001322994,0.0003639963,0.00004047968,0.0000371603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001399339,0.0001236366,0.001476682,0.00001441041,0.0000136814,0.00002944363,0.00005688026,0.0006084249,0.9957697,0.0007959537,0.0002511397,0.0007201332],"study_design_scores_gemma":[0.0008049985,0.001077676,0.002932845,0.000004546512,0.000009037632,0.00007762478,0.00007447157,0.00008702734,0.9727492,0.0002802973,0.02169677,0.0002054895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977437,0.0005388403,0.0001464958,0.0002254126,0.0001137226,0.0003581357,0.00005290505,0.00001157417,0.0008092612],"genre_scores_gemma":[0.9987258,0.0000253364,0.0001948277,0.0005120446,0.00002352389,0.0001485176,0.0002703498,0.00002581657,0.00007378571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02302047,"threshold_uncertainty_score":0.5713665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01347625874718418,"score_gpt":0.2502044465654631,"score_spread":0.2367281878182789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}