{"id":"W4280641517","doi":"10.21203/rs.3.rs-1634423/v1","title":"Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Milk Quality and Mastitis in Dairy Cows","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université Laval; McGill University; Agriculture and Agri-Food Canada","funders":"","keywords":"Streptococcus uberis; DNA methylation; Transcriptome; Biology; Subclinical infection; Methylation; Genetics; Computational biology; Microbiology; Streptococcus; DNA; Gene; Bacteria; Gene expression; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005410147,0.0003128797,0.0006036636,0.001078944,0.0002777578,0.0005060336,0.0002236184,0.0002908008,0.001815241],"category_scores_gemma":[0.0007794248,0.0001757389,0.0005489309,0.001012529,0.0001129352,0.0003596384,0.0006510817,0.0003005063,0.0004124671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002276379,"about_ca_system_score_gemma":0.0004239476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001930756,"about_ca_topic_score_gemma":0.00478591,"domain_scores_codex":[0.9995531,0.0000804165,0.00003299037,0.0001784329,0.00008622587,0.00006876913],"domain_scores_gemma":[0.9996616,0.00009042288,0.00009347319,0.0000363505,0.00007530355,0.00004287419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001215829,0.0001048733,0.1801806,0.0006921082,0.0006330576,0.0002264811,0.0003123062,0.001766517,0.7652102,0.0001864181,0.001137088,0.04833442],"study_design_scores_gemma":[0.00004763265,0.0005363546,0.8733092,0.0000911864,0.0006944049,0.0005404138,0.0006079297,0.02771332,0.08736823,0.000691577,0.00834632,0.00005351613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9699327,0.002523112,0.01095389,0.0001720967,0.00003073045,0.00004867583,0.01470228,0.0004339075,0.001202504],"genre_scores_gemma":[0.9553742,0.0007040084,0.01774472,0.0001152595,0.00003041927,0.0001020197,0.02462946,0.00006150267,0.001238419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001930756,"threshold_uncertainty_score":0.006072521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1189874138595006,"score_gpt":0.3931136118620449,"score_spread":0.2741261980025443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}