{"id":"W4280642331","doi":"10.3390/vaccines10050775","title":"Epitope Profiling of Diphtheria Toxoid Provides Enhanced Monitoring for Consistency Testing during Manufacturing Process Changes","year":2022,"lang":"en","type":"article","venue":"Vaccines","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sanofi (Canada)","funders":"Sanofi Pasteur; Sanofi","keywords":"Antigenicity; Epitope; Computational biology; Profiling (computer programming); Monoclonal antibody; Context (archaeology); Computer science; Diphtheria; Traceability; Antigen; Medicine; Antibody; Biology; Virology; Immunology; Software engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002511854,0.0002138594,0.000357016,0.0001343596,0.0007243627,0.00001608942,0.0003022898,0.00007961718,0.0001201515],"category_scores_gemma":[0.0002082706,0.0002021742,0.00007753383,0.0001436665,0.0000250781,0.0001049478,0.0001918976,0.0002108883,0.000003657098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004455025,"about_ca_system_score_gemma":0.00005962486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003215945,"about_ca_topic_score_gemma":0.000004643735,"domain_scores_codex":[0.9987326,0.00007095896,0.0003657739,0.000360678,0.00005141937,0.0004185668],"domain_scores_gemma":[0.9991432,0.0001817456,0.0003040991,0.0002460833,0.0001091706,0.0000156624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002474165,0.00007187499,0.00143261,0.0003528255,0.00008035886,0.000001301781,0.0006791737,0.0001495102,0.9900616,0.00004577438,0.000003493703,0.006874101],"study_design_scores_gemma":[0.001092634,0.0003885408,0.002757001,0.0000971058,0.00003614902,0.0000301839,0.002900102,0.00001107531,0.9919999,0.0002461471,0.0002110932,0.000230049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951761,0.002274361,0.0001085013,0.00006413636,0.001210475,0.0008752128,0.00005199267,0.0001285502,0.0001107155],"genre_scores_gemma":[0.9966533,0.00002717158,0.001802789,0.000010879,0.0001154711,0.0007678451,0.00002058977,0.00004197253,0.0005600439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006644052,"threshold_uncertainty_score":0.8244424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0232281866596831,"score_gpt":0.257372746616836,"score_spread":0.2341445599571529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}