{"id":"W4280642331","doi":"10.3390/vaccines10050775","title":"Epitope Profiling of Diphtheria Toxoid Provides Enhanced Monitoring for Consistency Testing during Manufacturing Process Changes","year":2022,"lang":"en","type":"article","venue":"Vaccines","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sanofi (Canada)","funders":"Sanofi Pasteur; Sanofi","keywords":"Antigenicity; Epitope; Computational biology; Profiling (computer programming); Monoclonal antibody; Context (archaeology); Computer science; Diphtheria; Traceability; Antigen; Medicine; Antibody; Biology; Virology; Immunology; Software engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001238035,0.0004274578,0.0003244804,0.000661841,0.0002021337,0.0006107355,0.0003251905,0.0004328759,0.0009115826],"category_scores_gemma":[0.001669102,0.0002416506,0.0002724064,0.0003957049,0.0002844526,0.0004705505,0.0004395592,0.0006024678,0.0003188751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002829077,"about_ca_system_score_gemma":0.0002400244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004911153,"about_ca_topic_score_gemma":0.0008439152,"domain_scores_codex":[0.9988043,0.0002093544,0.00007240687,0.0001810527,0.000641478,0.00009130792],"domain_scores_gemma":[0.9989518,0.0002964245,0.0002464216,0.0001526521,0.0003153211,0.00003732809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008999591,0.00002854612,0.002505655,0.00003602224,0.000006509409,0.00002402055,0.00004211098,0.0002848835,0.9884674,0.0000849757,0.00004380444,0.008386148],"study_design_scores_gemma":[0.000003526306,0.0003427099,0.008065781,0.000004336007,0.00001162107,0.0001131724,0.00003533956,0.002231337,0.9883854,0.00006346838,0.0007344782,0.000008771197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9087794,0.0007205285,0.08675949,0.0001130516,0.00005327947,0.000141156,0.0005576799,0.0004384784,0.002436921],"genre_scores_gemma":[0.948577,0.000522516,0.0484151,0.000110343,0.00001265455,0.00006694215,0.000366606,0.00005066448,0.001878082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001238035,"threshold_uncertainty_score":0.006547451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0232281866596831,"score_gpt":0.257372746616836,"score_spread":0.2341445599571529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}