{"id":"W4280651407","doi":"10.1158/1078-0432.ccr-21-3811","title":"VERONICA: Randomized Phase II Study of Fulvestrant and Venetoclax in ER-Positive Metastatic Breast Cancer Post-CDK4/6 Inhibitors – Efficacy, Safety, and Biomarker Results","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Regional Cancer Foundation; Ottawa Hospital; Sunnybrook Health Science Centre","funders":"Roche","keywords":"Fulvestrant; Venetoclax; Internal medicine; Medicine; Metastatic breast cancer; Oncology; Cancer; Clinical endpoint; Breast cancer; Hazard ratio; Estrogen receptor; Randomized controlled trial; Confidence interval; Leukemia; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.007709491,0.0002968519,0.001665104,0.0004464665,0.0003869279,0.00002145805,0.0002437935,0.00008599925,0.0002919472],"category_scores_gemma":[0.0009939471,0.0002456011,0.000167952,0.0009980707,0.001653967,0.0001250778,0.0007560672,0.001404627,0.000001031181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007795745,"about_ca_system_score_gemma":0.00148708,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007037489,"about_ca_topic_score_gemma":0.001224469,"domain_scores_codex":[0.9925726,0.002821132,0.001696083,0.0009939309,0.001242771,0.0006734648],"domain_scores_gemma":[0.9943175,0.003945846,0.0003403799,0.0005241305,0.0004872963,0.0003848924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7955385,0.004352515,0.003258734,0.000143396,0.0009716526,0.0002325277,0.00415129,0.0002174033,0.002009065,0.00003136621,0.0001076637,0.1889858],"study_design_scores_gemma":[0.8150595,0.01425129,0.1598101,0.0006627204,0.0005052732,0.00012514,0.006206076,0.0007668412,0.0002502483,0.0001677846,0.00177842,0.0004165972],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806836,0.007643286,0.000005340207,0.006015955,0.0002301461,0.004162268,0.001165499,0.00002457614,0.00006934868],"genre_scores_gemma":[0.9959809,0.002447652,0.00006339853,0.0001883027,0.0001485255,0.0009069135,0.00004142606,0.00005616338,0.0001667054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1885692,"threshold_uncertainty_score":0.9999996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1138370928994415,"score_gpt":0.5007041477483942,"score_spread":0.3868670548489528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}