{"id":"W4280651407","doi":"10.1158/1078-0432.ccr-21-3811","title":"VERONICA: Randomized Phase II Study of Fulvestrant and Venetoclax in ER-Positive Metastatic Breast Cancer Post-CDK4/6 Inhibitors – Efficacy, Safety, and Biomarker Results","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Regional Cancer Foundation; Ottawa Hospital; Sunnybrook Health Science Centre","funders":"Roche","keywords":"Fulvestrant; Venetoclax; Internal medicine; Medicine; Metastatic breast cancer; Oncology; Cancer; Clinical endpoint; Breast cancer; Hazard ratio; Estrogen receptor; Randomized controlled trial; Confidence interval; Leukemia; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001934036,0.001222147,0.001365533,0.0004622401,0.0002682764,0.001134781,0.0009422402,0.001238458,0.006808086],"category_scores_gemma":[0.001275765,0.0005223174,0.0008613778,0.0005084894,0.001289812,0.0007775942,0.0004088123,0.002190469,0.0009004711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008475358,"about_ca_system_score_gemma":0.001364285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001099739,"about_ca_topic_score_gemma":0.003033878,"domain_scores_codex":[0.9994295,0.0003395832,0.0000197461,0.00008687814,0.00003991197,0.00008426271],"domain_scores_gemma":[0.9991143,0.0001770509,0.0001954436,0.00009472765,0.00004330335,0.0003751192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9354584,0.019597,0.001305622,0.0003241011,0.0005326711,0.00006291243,0.00007431604,0.0006398088,0.01200973,0.0002943122,0.001208376,0.02849271],"study_design_scores_gemma":[0.8767454,0.1174434,0.003151263,0.00002085519,0.0002219129,0.00006204066,0.00002670818,0.0004628325,0.0007881829,0.0001464866,0.0009171966,0.00001376722],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892303,0.002699014,0.000531719,0.0004745054,0.0002620326,0.002977026,0.001096785,0.0001078883,0.002620634],"genre_scores_gemma":[0.988206,0.001482281,0.001096402,0.0007251665,0.0001838381,0.001844947,0.001824727,0.00002192816,0.004614552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006808086,"threshold_uncertainty_score":0.02277529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1138370928994415,"score_gpt":0.5007041477483942,"score_spread":0.3868670548489528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}