{"id":"W4280651915","doi":"10.1055/a-1850-3687","title":"Palladium-Catalyzed Cross-Coupling of Cyanohydrins with Aryl Bromides: Construction of Biaryl Ketones","year":2022,"lang":"en","type":"article","venue":"Synthesis","topic":"Catalytic C–H Functionalization Methods","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; Queen's University; Hunan Provincial Science and Technology Department; Canada Research Chairs; Government of Ontario","keywords":"Chemistry; Palladium; Aryl; Cyanohydrin; Catalysis; Combinatorial chemistry; Coupling reaction; Lithium (medication); Organic chemistry; Fluoride; Inorganic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004210965,0.0001725919,0.0003706941,0.0001333288,0.0001703718,0.00001661277,0.0002439756,0.00007022815,0.007830977],"category_scores_gemma":[0.0003246742,0.0001756595,0.0001365987,0.0004518738,0.0003203846,0.0001010164,0.0001293885,0.0001386892,0.000004858343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001184897,"about_ca_system_score_gemma":0.0001694365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001537929,"about_ca_topic_score_gemma":0.000005623845,"domain_scores_codex":[0.9984317,0.00001414926,0.0005219963,0.0003344067,0.0005162621,0.0001814386],"domain_scores_gemma":[0.9980705,0.0007299015,0.000468133,0.0005091073,0.0001653729,0.0000570062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004875167,0.0001733951,0.07630331,0.0006073219,0.0003562473,0.000007955769,0.0002272268,0.01319525,0.9051995,0.001080891,0.0000287163,0.002332698],"study_design_scores_gemma":[0.0004639022,0.0000156599,0.002722705,0.0001000277,0.0001551302,0.00009348129,0.0008152831,0.001694756,0.9930903,0.0002525623,0.0003847994,0.0002114176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959379,0.0001101791,0.001683922,0.00004397483,0.0001388159,0.00007793304,0.0002572237,0.00007372301,0.00167631],"genre_scores_gemma":[0.9937627,0.00002142459,0.005606061,0.000005264335,0.00005796101,0.00007582525,0.00007731234,0.00004215106,0.0003512714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0878908,"threshold_uncertainty_score":0.993076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01784619425471529,"score_gpt":0.2658390020714532,"score_spread":0.2479928078167379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}