{"id":"W4280654322","doi":"10.1126/science.abl5311","title":"Universal antigen encoding of T cell activation from high-dimensional cytokine dynamics","year":2022,"lang":"en","type":"article","venue":"Science","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institutes of Health","keywords":"Antigen; Immune system; Encoding (memory); T cell; Chimeric antigen receptor; Biology; Cell biology; Immunology; Computational biology; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002496283,0.00008377434,0.0001353838,0.0001625528,0.0005481434,0.000005461623,0.0004493701,0.0000538487,0.001188655],"category_scores_gemma":[0.00002164086,0.00008186459,0.00003323652,0.0004242106,0.0006255103,0.000137439,0.0004073142,0.0002279198,0.0000569732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001400568,"about_ca_system_score_gemma":0.0002053599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006204514,"about_ca_topic_score_gemma":0.00001172916,"domain_scores_codex":[0.9991423,0.00008394432,0.0001533146,0.000289401,0.00008380455,0.0002472624],"domain_scores_gemma":[0.9994957,0.00008795976,0.0001349723,0.0002088964,0.00005995592,0.0000124774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000568664,0.00009524606,0.001165568,0.000001291249,0.00001034639,0.000002263324,0.0002079552,0.0002200022,0.9963415,0.001259645,0.00008957441,0.000549747],"study_design_scores_gemma":[0.0005708538,0.0001481189,0.004576892,0.000003926663,0.000007128959,0.00000751225,0.0005528986,0.0002493412,0.9915422,0.0003471932,0.001894818,0.00009917315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974125,0.00013929,0.0002177578,0.0001488835,0.00096497,0.00006961436,0.00008982947,0.00002777946,0.0009294004],"genre_scores_gemma":[0.9983957,0.000009056418,0.0002390499,0.00006134335,0.000008972224,0.000002402303,0.0001314332,0.000004777311,0.001147262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004799352,"threshold_uncertainty_score":0.9997244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008209756815364405,"score_gpt":0.2030349608517082,"score_spread":0.1948252040363438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}