{"id":"W4280654651","doi":"10.1101/2022.05.06.490968","title":"Single-Cell RNAseq Analysis Reveals Robust, Anti-PD-1-Mediated Increase of Immune Infiltrate in Metastatic Castration-Sensitive Prostate Cancer","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"National Institutes of Health; Conquer Cancer Foundation; Regeneron Pharmaceuticals; Prostate Cancer Foundation","keywords":"Prostate cancer; Immune system; Androgen deprivation therapy; Immunotherapy; Tumor microenvironment; Medicine; Druggability; Context (archaeology); Oncology; Castration; Cancer; Prostate; Metastasis; Cancer research; Hormonal therapy; Internal medicine; Immunology; Biology; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001877221,0.0001440789,0.0002180678,0.0003360244,0.0001762568,0.0003342021,0.00009569054,0.0001848536,0.001269269],"category_scores_gemma":[0.0001496404,0.00008413384,0.0001377655,0.000184272,0.000245009,0.00008198434,0.0001428918,0.000439965,0.0003440252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001828991,"about_ca_system_score_gemma":0.0001511664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005238451,"about_ca_topic_score_gemma":0.000736583,"domain_scores_codex":[0.9998741,0.00001225535,0.000006164854,0.0000430596,0.00004249119,0.00002192188],"domain_scores_gemma":[0.9999034,0.00002045493,0.00001443781,0.00001207174,0.00002043236,0.0000292285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009859678,0.00001479377,0.001874108,0.00001887754,0.000006910925,0.00002302146,0.00003404864,0.0001059884,0.9963761,0.00004031762,0.0001213614,0.001285819],"study_design_scores_gemma":[0.00004830573,0.0005349371,0.160725,0.00000759367,0.00003226022,0.0007199005,0.0002000613,0.006672916,0.8253666,0.0002736097,0.005404642,0.00001421271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910707,0.001001396,0.004550365,0.000109444,0.0000232027,0.00003363119,0.001961473,0.0001303384,0.001119501],"genre_scores_gemma":[0.9935204,0.0002462687,0.002856304,0.0001166137,0.00001154626,0.00004965164,0.001649305,0.00002983484,0.001520136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001269269,"threshold_uncertainty_score":0.004246175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02019821163937235,"score_gpt":0.2469894905103318,"score_spread":0.2267912788709595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}