{"id":"W4281252213","doi":"10.1002/cpz1.429","title":"Freshly Isolated Hepatocytes from Chimeric Humanized Liver Mice for the <i>In Vitro</i> Assessment of Drug Metabolism, Inhibition/Induction, and Safety Studies","year":2022,"lang":"en","type":"article","venue":"Current Protocols","topic":"Liver physiology and pathology","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"KMT Hepatech (Canada)","funders":"","keywords":"In vitro; Drug metabolism; Biology; Hepatocyte; Cryopreservation; Drug development; In vivo; Drug; Cell biology; Cell; In vitro toxicology; Pharmacology; Immunology; Computational biology; Biochemistry; Biotechnology; Embryo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004440834,0.0001500113,0.0004789532,0.00007271664,0.0002958576,0.000005297436,0.00009235684,0.00003478687,0.0001117997],"category_scores_gemma":[0.00004772466,0.0001070599,0.00008696983,0.0001678161,0.0001926884,0.00007606364,0.0001729365,0.0003530648,0.000001686204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005400028,"about_ca_system_score_gemma":0.0001003993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003869601,"about_ca_topic_score_gemma":0.000006183019,"domain_scores_codex":[0.9986798,0.0003248842,0.0003817979,0.0003021226,0.0001409734,0.0001704748],"domain_scores_gemma":[0.9990293,0.0003843381,0.0002118365,0.0002171825,0.0001265214,0.00003082191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.02200071,0.004880785,0.03691878,0.002404783,0.002143725,0.00003807103,0.02039351,0.0001338476,0.867144,0.005357762,0.01170965,0.02687435],"study_design_scores_gemma":[0.05075645,0.002892045,0.5945447,0.001012653,0.00203955,0.0001031767,0.005379182,0.006440183,0.1135735,0.009776028,0.2123014,0.001181104],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8761063,0.007964386,0.0004000422,0.0006538361,0.0005047804,0.1138405,0.0004405415,0.00005071616,0.00003892879],"genre_scores_gemma":[0.7702608,0.0003110299,0.0007941672,0.0003121523,0.0002425113,0.2277584,0.0002218241,0.00002148626,0.00007767085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7535705,"threshold_uncertainty_score":0.4365776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06233179054687144,"score_gpt":0.3745347500831164,"score_spread":0.312202959536245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}