{"id":"W4281252213","doi":"10.1002/cpz1.429","title":"Freshly Isolated Hepatocytes from Chimeric Humanized Liver Mice for the <i>In Vitro</i> Assessment of Drug Metabolism, Inhibition/Induction, and Safety Studies","year":2022,"lang":"en","type":"article","venue":"Current Protocols","topic":"Liver physiology and pathology","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"KMT Hepatech (Canada)","funders":"","keywords":"In vitro; Drug metabolism; Biology; Hepatocyte; Cryopreservation; Drug development; In vivo; Drug; Cell biology; Cell; In vitro toxicology; Pharmacology; Immunology; Computational biology; Biochemistry; Biotechnology; Embryo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009852237,0.0008302341,0.0004014833,0.0008446448,0.0003557614,0.0005645254,0.0005499363,0.0007454096,0.007301275],"category_scores_gemma":[0.0003200324,0.0003923306,0.0006636088,0.0004442444,0.0004870019,0.0005407505,0.0003125512,0.001736622,0.003277768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003973432,"about_ca_system_score_gemma":0.0004970666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008997833,"about_ca_topic_score_gemma":0.00173611,"domain_scores_codex":[0.9994712,0.00007764952,0.00008175857,0.0001545946,0.0001404982,0.00007431194],"domain_scores_gemma":[0.9994635,0.00009983867,0.0001121926,0.0001474559,0.00008884884,0.00008805676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004444894,0.0001244872,0.0001477093,0.00006962748,0.00001003388,0.00008658778,0.00002976015,0.0000747482,0.9960399,0.000358947,0.0005062959,0.002107427],"study_design_scores_gemma":[0.00004270873,0.0004827368,0.001209388,0.00001168598,0.00002276928,0.0001560969,0.0000196667,0.0002924694,0.9930959,0.00006158085,0.004597284,0.000007610391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.7504098,0.005668977,0.1606993,0.001366162,0.001325885,0.005114431,0.04113121,0.004563922,0.02972036],"genre_scores_gemma":[0.8117347,0.0039919,0.104589,0.001097188,0.0001624081,0.006147082,0.02454232,0.001301116,0.04643434],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.007301275,"threshold_uncertainty_score":0.02442521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06233179054687144,"score_gpt":0.3745347500831164,"score_spread":0.312202959536245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}