{"id":"W4281252334","doi":"10.1007/s40265-022-01722-2","title":"New Topical Therapies in Development for Atopic Dermatitis","year":2022,"lang":"en","type":"review","venue":"Drugs","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"Probity Medical Research; Queen's University","funders":"","keywords":"Medicine; Atopic dermatitis; Dupilumab; Roflumilast; Intensive care medicine; Apremilast; Dermatology; Disease; Calcineurin; Drug development; Ruxolitinib; Adverse effect; Drug; Pharmacology; Psoriasis; Surgery; Internal medicine; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005554847,0.00120188,0.001950769,0.002631168,0.0002128295,0.000950255,0.0006737226,0.0009635492,0.007607903],"category_scores_gemma":[0.0006041158,0.0003319508,0.000795951,0.001866165,0.0003290378,0.001045043,0.0006248855,0.002077617,0.002133058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003739241,"about_ca_system_score_gemma":0.0007727609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008716343,"about_ca_topic_score_gemma":0.00287917,"domain_scores_codex":[0.9998422,0.0000278367,0.00002663266,0.00002377561,0.00005837524,0.00002115968],"domain_scores_gemma":[0.9997342,0.0001288649,0.00005432423,0.000008698376,0.00004571968,0.00002806171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001820601,0.0001211146,0.0001201736,0.0274491,0.0001633745,0.0001637559,0.0000341469,0.000254189,0.001919135,0.00132972,0.01844262,0.9498205],"study_design_scores_gemma":[0.0002439275,0.0003783409,0.001438282,0.01136631,0.00100704,0.001399017,0.00006892729,0.0001822684,0.0008572628,0.001360903,0.981669,0.00002879275],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001370818,0.9981776,0.0001181673,0.0001132501,0.0001737684,0.00001367339,0.00003009784,0.000009642543,0.001226687],"genre_scores_gemma":[0.0007628282,0.9978324,0.0002547966,0.000221303,0.000119916,0.00001187928,0.00003849896,0.00000186487,0.0007565399],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007607903,"threshold_uncertainty_score":0.025451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04522105744302725,"score_gpt":0.3383699868870051,"score_spread":0.2931489294439779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}