{"id":"W4281253995","doi":"10.1021/acs.molpharmaceut.1c00916","title":"Lipid-Nanoparticle-Based Delivery of CRISPR/Cas9 Genome-Editing Components","year":2022,"lang":"en","type":"review","venue":"Molecular Pharmaceutics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":292,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; Huntington Society of Canada","keywords":"CRISPR; Genome editing; Cas9; Computational biology; Flexibility (engineering); Genome; Computer science; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003078416,0.0005108759,0.0008558349,0.0001618819,0.00009696028,0.00002390972,0.0005766442,0.0002456919,0.0001391081],"category_scores_gemma":[0.00005345264,0.0005634309,0.0006503509,0.0002827754,0.00007664201,0.000002293093,0.0004320396,0.0004118243,0.00001191559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006163764,"about_ca_system_score_gemma":0.0002092592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005615144,"about_ca_topic_score_gemma":7.588907e-7,"domain_scores_codex":[0.9976078,0.0002333666,0.0007104016,0.0005777644,0.0003792357,0.0004914861],"domain_scores_gemma":[0.9987119,0.00003998605,0.0003249885,0.0006714052,0.00006870408,0.0001829512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004506122,0.0004021226,0.00002121456,0.01502186,0.001008065,0.0001815334,0.00004131777,0.008642422,0.5467309,0.00001528279,0.0003863211,0.4275039],"study_design_scores_gemma":[0.0004266981,0.0001000151,0.000001067014,0.0002990089,0.0007237733,0.00003020358,0.00001035243,0.0005135692,0.1279779,8.221291e-7,0.8694778,0.0004387363],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002932727,0.9897566,0.00580735,0.00001078239,0.000514132,0.0005795508,0.0001894664,0.00003044369,0.0001789099],"genre_scores_gemma":[0.01045875,0.9868022,0.0007864,0.0001876153,0.0002817881,0.0001078192,0.001159278,0.0001648249,0.00005134888],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8690915,"threshold_uncertainty_score":0.9996817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06195739273668328,"score_gpt":0.3851739935016361,"score_spread":0.3232166007649528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}