{"id":"W4281253995","doi":"10.1021/acs.molpharmaceut.1c00916","title":"Lipid-Nanoparticle-Based Delivery of CRISPR/Cas9 Genome-Editing Components","year":2022,"lang":"en","type":"review","venue":"Molecular Pharmaceutics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":292,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; Huntington Society of Canada","keywords":"CRISPR; Genome editing; Cas9; Computational biology; Flexibility (engineering); Genome; Computer science; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002100643,0.000567396,0.000596326,0.00131766,0.0001788642,0.0005188356,0.0003838476,0.0006693923,0.00161615],"category_scores_gemma":[0.0001833285,0.0002084597,0.0003305786,0.0008699827,0.0001686804,0.0005964024,0.0003931112,0.0007750017,0.001227743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004082799,"about_ca_system_score_gemma":0.0005766728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007681791,"about_ca_topic_score_gemma":0.001289866,"domain_scores_codex":[0.9999182,0.00001127585,0.000007271565,0.00001566368,0.00003519978,0.00001236991],"domain_scores_gemma":[0.9999532,0.00001823601,0.000008709505,0.00000164681,0.00001279056,0.000005550117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006184141,0.0001147716,0.0001402955,0.01829198,0.00008335634,0.0004832007,0.00006952213,0.0008423462,0.04253864,0.008223313,0.0177598,0.911391],"study_design_scores_gemma":[0.00001139588,0.0001361856,0.0004400297,0.00132793,0.00007943414,0.001365541,0.00004237994,0.0003128481,0.01392857,0.001416341,0.9809155,0.00002386567],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001329,0.9917181,0.00144144,0.0003579425,0.0002381093,0.00002398312,0.00005446721,0.00003931452,0.004797654],"genre_scores_gemma":[0.005138573,0.9898369,0.001191121,0.000208354,0.00006831479,0.00002566005,0.00007710922,0.000005648992,0.003448419],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00161615,"threshold_uncertainty_score":0.005406559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06195739273668328,"score_gpt":0.3851739935016361,"score_spread":0.3232166007649528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}