{"id":"W4281256116","doi":"10.3390/pathogens11050602","title":"Redirecting Imipramine against Bluetongue Virus Infection: Insights from a Genome-wide Haploid Screening Study","year":2022,"lang":"en","type":"article","venue":"Pathogens","topic":"Vector-Borne Animal Diseases","field":"Agricultural and Biological Sciences","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Horizon 2020 Framework Programme","keywords":"Imipramine; Virology; NPC1; Biology; Virus; Arbovirus; In vitro; Outbreak; Genome; Host factor; Intracellular; Medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003124665,0.0002856941,0.0003246599,0.0002806497,0.0001381363,0.0002944062,0.0002072597,0.0002744539,0.0006742332],"category_scores_gemma":[0.0001673158,0.0001041869,0.0002706048,0.0001618486,0.0001583003,0.0001367425,0.0001782054,0.0003292701,0.000166397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002457542,"about_ca_system_score_gemma":0.0001814401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008165864,"about_ca_topic_score_gemma":0.001672278,"domain_scores_codex":[0.9999139,0.00001679027,0.000009812617,0.00001983043,0.00002585892,0.00001380962],"domain_scores_gemma":[0.9999224,0.00002467256,0.00001803173,0.00000777861,0.000014351,0.00001283658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009072838,0.00002627383,0.0008485846,0.00005181912,0.00001562397,0.00005734622,0.00002499996,0.0002279593,0.9956396,0.00005233513,0.00005798459,0.002906716],"study_design_scores_gemma":[0.00005908635,0.001253127,0.03069136,0.00001803044,0.0001894449,0.0006988732,0.0001877307,0.006868814,0.9520748,0.0001300709,0.007800104,0.00002856673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895346,0.002707364,0.005204052,0.0001639299,0.00001576056,0.0000601041,0.00140602,0.00009024518,0.0008179354],"genre_scores_gemma":[0.9850224,0.002530422,0.008148035,0.0001205156,0.000005541582,0.00005427269,0.002721718,0.00003648529,0.001360547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008165864,"threshold_uncertainty_score":0.002255559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02774325687735516,"score_gpt":0.2229960006478127,"score_spread":0.1952527437704575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}