{"id":"W4281258754","doi":"10.1093/brain/awac187","title":"Brain atrophy in prodromal synucleinopathy is shaped by structural connectivity and gene expression","year":2022,"lang":"en","type":"article","venue":"Brain","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo; Université de Montréal; Montreal General Hospital; Institut Universitaire de Gériatrie de Montréal; Université du Québec à Montréal; University of Calgary; McGill University; Hôpital du Sacré-Cœur de Montréal; Montreal Neurological Institute and Hospital","funders":"National Health and Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Jascha Fonden; Lundbeckfonden; Agence Nationale de la Recherche; W. Garfield Weston Foundation; Biogen","keywords":"Atrophy; Neuroscience; Gene expression; Pathology; Gene; Biology; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002713574,0.0003307236,0.0001996063,0.0002151019,0.0001383035,0.000255506,0.0002232235,0.0002936303,0.0006829258],"category_scores_gemma":[0.001230929,0.000178299,0.0003800077,0.0001135304,0.0004402555,0.0001880601,0.0002197127,0.0002430242,0.0001032969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003892158,"about_ca_system_score_gemma":0.0002253072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005976839,"about_ca_topic_score_gemma":0.007295225,"domain_scores_codex":[0.9999026,0.000040517,0.000003832136,0.00003256632,0.000008214872,0.00001221058],"domain_scores_gemma":[0.9997539,0.0001223585,0.00006503933,0.00002442171,0.00001552941,0.00001872341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.0009238179,0.0002382462,0.3003511,0.00007678455,0.0003678919,0.001010499,0.0003464466,0.6584389,0.02582673,0.002161423,0.0004259952,0.00983221],"study_design_scores_gemma":[0.000064614,0.0006240482,0.1791307,0.00001742939,0.0001055926,0.0005230102,0.000213256,0.8114235,0.003651233,0.003867732,0.0003572807,0.00002142403],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979337,0.00002735099,0.001778865,0.00002638482,0.000001398667,0.000004896767,0.00005847769,0.00001301585,0.0001559002],"genre_scores_gemma":[0.999241,0.00003011778,0.0005132102,0.000005706579,7.901728e-7,0.000006057879,0.0000673558,0.000003221939,0.0001324443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005976839,"threshold_uncertainty_score":0.01188409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009817400718718986,"score_gpt":0.2464740866636833,"score_spread":0.2366566859449644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}