{"id":"W4281258754","doi":"10.1093/brain/awac187","title":"Brain atrophy in prodromal synucleinopathy is shaped by structural connectivity and gene expression","year":2022,"lang":"en","type":"article","venue":"Brain","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo; Université de Montréal; Montreal General Hospital; Institut Universitaire de Gériatrie de Montréal; Université du Québec à Montréal; University of Calgary; McGill University; Hôpital du Sacré-Cœur de Montréal; Montreal Neurological Institute and Hospital","funders":"National Health and Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Jascha Fonden; Lundbeckfonden; Agence Nationale de la Recherche; W. Garfield Weston Foundation; Biogen","keywords":"Atrophy; Neuroscience; Gene expression; Pathology; Gene; Biology; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001507956,0.0001625947,0.0002482909,0.00008897143,0.000170009,0.00001610488,0.00006194615,0.00004298766,0.0004871985],"category_scores_gemma":[0.00006605663,0.0001467816,0.00005528265,0.000144191,0.00002959571,0.00007085547,0.0001486629,0.0001582376,0.000005478453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001143073,"about_ca_system_score_gemma":0.0000510054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000985438,"about_ca_topic_score_gemma":0.000005352299,"domain_scores_codex":[0.9987681,0.0001374358,0.0001486195,0.0004311049,0.0002676225,0.0002470991],"domain_scores_gemma":[0.999512,0.00006229121,0.00005830674,0.0002020153,0.00001198737,0.0001534201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008881894,0.0003891314,0.06075058,0.00005412559,0.00006123433,0.0007123222,0.0009622481,0.000002205543,0.9197114,0.0001262122,0.007438877,0.00890346],"study_design_scores_gemma":[0.01841659,0.002400331,0.8594695,0.00008939524,0.0001232184,0.0005335556,0.0006195818,0.004150218,0.0904602,0.002525684,0.02050929,0.0007024703],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956775,0.0006020434,0.00002585722,0.002717647,0.0000727324,0.0005070043,0.0002544797,0.00004514488,0.00009755384],"genre_scores_gemma":[0.9968191,0.000004336997,0.0004103534,0.002020874,0.00003684678,0.00009755922,0.00009420957,0.0000255443,0.0004911995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8292512,"threshold_uncertainty_score":0.5985582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009817400718718986,"score_gpt":0.2464740866636833,"score_spread":0.2366566859449644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}