{"id":"W4281259838","doi":"10.1016/j.leukres.2022.106869","title":"NPM1-mutated AML-MRC diagnosed on the basis of history of MDS or MDS/MPN frequently harbours secondary-type mutations and confers inferior outcome compared to AML with mutated NPM1","year":2022,"lang":"en","type":"article","venue":"Leukemia Research","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; University Health Network; University of Toronto","funders":"Leukemia and Lymphoma Society of Canada; Cancer Research Society","keywords":"NPM1; Internal medicine; Oncology; Medicine; Myeloid leukemia; Proportional hazards model; Exact test; Survival analysis; Biology; Genetics; Karyotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002616726,0.0001898591,0.0004494448,0.0006500553,0.00024841,0.000392461,0.0002036866,0.0002612214,0.003740938],"category_scores_gemma":[0.001100143,0.00005947446,0.0001993752,0.0003140147,0.0002617996,0.0001675442,0.0003977267,0.0002124688,0.0007061235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003785545,"about_ca_system_score_gemma":0.0002635146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008906157,"about_ca_topic_score_gemma":0.001531966,"domain_scores_codex":[0.9997792,0.00003867202,0.00002214812,0.0000447459,0.00005503037,0.00006018756],"domain_scores_gemma":[0.9992133,0.0001746047,0.0002413706,0.00007521984,0.00004240969,0.0002531028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003446629,0.0001902497,0.8790632,0.0001134395,0.000155792,0.007996007,0.0001556402,0.0005449782,0.07348219,0.0008462715,0.0008089045,0.03319671],"study_design_scores_gemma":[0.00004617711,0.0009631854,0.9518729,0.00002975005,0.00008927497,0.03195261,0.0001959257,0.0007209496,0.01041047,0.0004978047,0.003208084,0.00001293217],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962006,0.0002424516,0.0002018204,0.00004780018,0.00001169172,0.00001290692,0.000325772,0.00001774469,0.002939239],"genre_scores_gemma":[0.9991102,0.00006365281,0.0001421465,0.00001253266,0.000008645532,0.000003448384,0.0003705019,0.000004208958,0.0002846381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003740938,"threshold_uncertainty_score":0.01251465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.103977293202742,"score_gpt":0.3633612639273743,"score_spread":0.2593839707246323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}