{"id":"W4281264061","doi":"10.1172/jci.insight.157164","title":"Response to supraphysiological testosterone is predicted by a distinct androgen receptor cistrome","year":2022,"lang":"en","type":"article","venue":"JCI Insight","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Institute of General Medical Sciences; National Cancer Institute; DOD Prostate Cancer Research Program; Foundation Medicine; Janssen Research and Development; National Institutes of Health; Institute for Prostate Cancer Research; U.S. Department of Defense; Sanofi; GlaxoSmithKline; Dana-Farber Cancer Institute; Pfizer; Foghorn Therapeutics; Bristol-Myers Squibb; Prostate Cancer Foundation; Doris Duke Charitable Foundation; Gilead Sciences; Mayer Foundation; Canadian Institutes of Health Research; University of Washington; Safeway Foundation","keywords":"Androgen receptor; Prostate cancer; Transcriptome; Androgen; Androgen deprivation therapy; Testosterone (patch); Internal medicine; Transcription factor; Medicine; Cancer research; Oncology; Endocrinology; Biology; Bioinformatics; Cancer; Hormone; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002394728,0.0001782089,0.0003803544,0.000289339,0.0001442524,0.0005548365,0.0001447356,0.0002105742,0.001978778],"category_scores_gemma":[0.0003864681,0.0001657395,0.0004259733,0.000254161,0.0002786668,0.0001586122,0.0002200497,0.0006192069,0.0004953798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002454401,"about_ca_system_score_gemma":0.0002731994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006468521,"about_ca_topic_score_gemma":0.001266859,"domain_scores_codex":[0.9998021,0.00002340339,0.000009673915,0.00006998725,0.0000534048,0.00004148711],"domain_scores_gemma":[0.9997076,0.00007108728,0.00008983602,0.00002920066,0.00004097962,0.00006122464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001308281,0.0001433391,0.06127546,0.0001285532,0.00008454709,0.0001209449,0.0001176182,0.0008870389,0.9234251,0.0002735801,0.0007276983,0.01150773],"study_design_scores_gemma":[0.00004003634,0.0007981347,0.9131939,0.00001716269,0.00008675547,0.0005407918,0.0002578975,0.00516083,0.07651237,0.0003823806,0.002970849,0.00003882439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928529,0.0008604815,0.002179248,0.0002009102,0.00003251531,0.00003114054,0.002218637,0.0001094271,0.001514714],"genre_scores_gemma":[0.9961553,0.0002794045,0.0007635525,0.0002258814,0.00001343531,0.00003023966,0.001643093,0.00003328743,0.0008558668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001978778,"threshold_uncertainty_score":0.006619692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02854666256671331,"score_gpt":0.2979925347984387,"score_spread":0.2694458722317254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}