{"id":"W4281287379","doi":"10.1186/s13075-022-02801-1","title":"Mass spectrometry-based proteomics identify novel serum osteoarthritis biomarkers","year":2022,"lang":"en","type":"article","venue":"Arthritis Research & Therapy","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Saint-Luc; Université Laval; Université de Montréal; Memorial University of Newfoundland; Centre Hospitalier de l’Université de Montréal","funders":"Arthritis Society","keywords":"Osteoarthritis; Proteomics; Medicine; Bioinformatics; Biomarker; Internal medicine; Computational biology; Biology; Pathology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002092035,0.000404325,0.0006083487,0.001116962,0.001341096,0.000206914,0.0004611706,0.0001507671,0.005497693],"category_scores_gemma":[0.0001180824,0.0004337742,0.0003766903,0.001859896,0.0003588005,0.0002426169,0.0002082429,0.001195186,0.0002602166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005376515,"about_ca_system_score_gemma":0.0006862213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001019853,"about_ca_topic_score_gemma":0.00007799011,"domain_scores_codex":[0.9940143,0.0005454455,0.0005541319,0.0009681103,0.002400441,0.001517527],"domain_scores_gemma":[0.9977975,0.0002113883,0.0001151645,0.0009860869,0.0003619436,0.0005279363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001824333,0.0009525646,0.002441428,0.0000229061,0.0001353161,0.001118464,0.0002028853,0.000005807062,0.8197509,0.0009237772,0.00123376,0.1713879],"study_design_scores_gemma":[0.1017909,0.05641234,0.004630532,0.0006651907,0.00005302853,0.001773755,0.003467047,0.000268293,0.6824043,0.00645326,0.140404,0.001677314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9730139,0.0102795,0.00105673,0.004787842,0.0006507842,0.00478796,0.0005507861,0.0003491819,0.004523286],"genre_scores_gemma":[0.9698923,0.001963676,0.02248082,0.000837787,0.000312855,0.002097709,0.0003361754,0.0001706345,0.001908052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1697105,"threshold_uncertainty_score":0.9999591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04950282730478136,"score_gpt":0.3397630350774707,"score_spread":0.2902602077726894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}