{"id":"W4281287651","doi":"10.1101/2022.05.19.492742","title":"Periostin <sup>+</sup> stromal cells guide lymphovascular invasion by cancer cells","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"University of Virginia; University of Minnesota; American Cancer Society; Melanoma Research Alliance; National Cancer Institute; National Institutes of Health","keywords":"Periostin; Stromal cell; Matricellular protein; Cancer-Associated Fibroblasts; Cancer cell; Pathology; Metastasis; Cancer; Cancer research; Desmoplasia; Medicine; Breast cancer; Tumor microenvironment; Lymph node stromal cell; Primary tumor; Biology; Pancreatic cancer; Cell biology; Internal medicine; Extracellular matrix","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001043776,0.001014141,0.001549971,0.000367404,0.0004077112,0.0002362572,0.0006134029,0.0008230196,0.001025162],"category_scores_gemma":[0.0001076032,0.00103719,0.001004715,0.0005901869,0.0001461292,0.0001250327,0.001360231,0.001527239,0.0000891001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001592971,"about_ca_system_score_gemma":0.002120274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009369578,"about_ca_topic_score_gemma":0.000001551894,"domain_scores_codex":[0.9943572,0.0002599348,0.001093872,0.001924288,0.001333631,0.001031084],"domain_scores_gemma":[0.9959435,0.00007823262,0.0004915735,0.002255723,0.0005610019,0.0006699829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009185417,0.0002303142,0.003818746,0.0009259628,0.0005114799,0.00009470578,0.00003199653,0.01119391,0.9675997,0.00001135786,0.01548288,0.000007095981],"study_design_scores_gemma":[0.002212296,0.0001581169,0.008014201,0.001396241,0.001195805,1.461563e-7,0.00003852354,0.009376279,0.8186508,2.129979e-7,0.1574259,0.001531485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833151,0.01047639,0.0004060937,0.0003222252,0.002072138,0.001563959,0.001318625,0.0004765468,0.00004900133],"genre_scores_gemma":[0.9865239,0.004842941,0.005287182,0.0008371191,0.001433866,0.000464431,0.000006212192,0.0004486121,0.0001557076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1489489,"threshold_uncertainty_score":0.9998881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01210432942862183,"score_gpt":0.2295432054531064,"score_spread":0.2174388760244846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}