{"id":"W4281287651","doi":"10.1101/2022.05.19.492742","title":"Periostin <sup>+</sup> stromal cells guide lymphovascular invasion by cancer cells","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"University of Virginia; University of Minnesota; American Cancer Society; Melanoma Research Alliance; National Cancer Institute; National Institutes of Health","keywords":"Periostin; Stromal cell; Matricellular protein; Cancer-Associated Fibroblasts; Cancer cell; Pathology; Metastasis; Cancer; Cancer research; Desmoplasia; Medicine; Breast cancer; Tumor microenvironment; Lymph node stromal cell; Primary tumor; Biology; Pancreatic cancer; Cell biology; Internal medicine; Extracellular matrix","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001059386,0.00022223,0.000160731,0.0001597164,0.000129213,0.0003218545,0.000117362,0.0001789863,0.002208408],"category_scores_gemma":[0.00007439161,0.0001190756,0.0001548237,0.0001008947,0.0001923302,0.0001441917,0.0002067999,0.0005328313,0.0007178122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002371283,"about_ca_system_score_gemma":0.0002014155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005545333,"about_ca_topic_score_gemma":0.0008179749,"domain_scores_codex":[0.9998831,0.00001678099,0.000009184576,0.00002379491,0.00003577515,0.00003142073],"domain_scores_gemma":[0.9998637,0.00002700356,0.00003282817,0.00001975525,0.00001642219,0.00004020481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005269849,0.00001148046,0.0001727205,0.00001644503,0.000001491674,0.00002278255,0.000009003644,0.00005997844,0.9986541,0.0001758676,0.00007282052,0.0007505185],"study_design_scores_gemma":[0.0000166402,0.000148987,0.003225923,0.000005643655,0.000006932645,0.0002321439,0.00003223409,0.002354794,0.9882286,0.00008359571,0.005661364,0.000003090286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847482,0.0009605745,0.009960539,0.0001704854,0.00006181095,0.00004771131,0.0005566732,0.0002177994,0.003276104],"genre_scores_gemma":[0.9870899,0.0003004538,0.005359538,0.00006411383,0.00001505651,0.00004573465,0.0004057958,0.0000450647,0.006674265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002208408,"threshold_uncertainty_score":0.007387877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01210432942862183,"score_gpt":0.2295432054531064,"score_spread":0.2174388760244846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}