{"id":"W4281288416","doi":"10.3389/fddsv.2022.892975","title":"Addressing Antibiotic Failure—Beyond Genetically Encoded Antimicrobial Resistance","year":2022,"lang":"en","type":"article","venue":"Frontiers in Drug Discovery","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"NanoMedicines Innovation Network; BC Innovation Council; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Antibiotics; Antibiotic resistance; Intensive care medicine; Sepsis; Medicine; Biology; Immunology; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004446659,0.000789416,0.001522924,0.001107336,0.00100033,0.004871509,0.001261852,0.004605911,0.00284316],"category_scores_gemma":[0.004654896,0.00026644,0.0007067248,0.0006651405,0.005095535,0.006835417,0.003543788,0.004971657,0.0009503351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001634322,"about_ca_system_score_gemma":0.003051989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005152858,"about_ca_topic_score_gemma":0.0009486995,"domain_scores_codex":[0.9980167,0.00078096,0.0001385487,0.0002256485,0.0004900127,0.0003479688],"domain_scores_gemma":[0.9946519,0.002875603,0.0009098771,0.0003827964,0.0007230789,0.0004567054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0003547587,0.0005264056,0.004611642,0.006281509,0.000140308,0.003244479,0.00191521,0.00179297,0.05491753,0.2154552,0.03557138,0.6751887],"study_design_scores_gemma":[0.00008092658,0.001662423,0.003420852,0.003758198,0.0001496595,0.009918657,0.003001675,0.002572805,0.03921226,0.1754233,0.7606158,0.0001834363],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.02490838,0.7177019,0.05237312,0.178674,0.003692489,0.0001090966,0.0001159922,0.0003800656,0.02204507],"genre_scores_gemma":[0.2303103,0.6720496,0.04315994,0.0407131,0.005984305,0.0001487227,0.0001249477,0.0001324112,0.007376725],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004871509,"threshold_uncertainty_score":0.02351642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008062339948502634,"score_gpt":0.2310799969258577,"score_spread":0.223017656977355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}