{"id":"W4281289922","doi":"10.1101/2022.05.20.492479","title":"CRISPR-Cas provides limited phage immunity to a prevalent gut bacterium in gnotobiotic mice","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Danish Agency for Science and Higher Education; Canadian Institutes of Health Research; Danmarks Frie Forskningsfond","keywords":"CRISPR; Biology; Virulence; Plasmid; Microbiology; Bacteria; In vivo; In vitro; DNA; Multiplicity of infection; Nucleic acid; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003605338,0.0009861148,0.0006839904,0.001200407,0.0002373348,0.0006125479,0.00048435,0.001019493,0.003211524],"category_scores_gemma":[0.0002614394,0.0004333001,0.0006265601,0.0002371545,0.0009352446,0.0004124227,0.0006011354,0.002185876,0.0007328783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004205437,"about_ca_system_score_gemma":0.0002749201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003926393,"about_ca_topic_score_gemma":0.0005267815,"domain_scores_codex":[0.9993549,0.00008131192,0.00007326253,0.0002138283,0.0001422042,0.0001344586],"domain_scores_gemma":[0.9990162,0.000111693,0.0003623573,0.0001162431,0.00004522495,0.0003482108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003254441,0.00008816297,0.0002430602,0.00003802833,0.000008356219,0.00006788594,0.00001588664,0.00005198382,0.9985252,0.00008750901,0.00002948337,0.0005190081],"study_design_scores_gemma":[0.0001018864,0.00187109,0.006437841,0.00002768894,0.00003830834,0.0006817819,0.00007781799,0.001527073,0.987156,0.0001479408,0.001912328,0.00002013111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916853,0.0005611777,0.004082153,0.0002275955,0.00006250211,0.00008901946,0.001106889,0.0004116289,0.001773715],"genre_scores_gemma":[0.9902524,0.0003437281,0.003471014,0.000190025,0.00002430831,0.0001315201,0.0007471342,0.0001103453,0.004729591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003211524,"threshold_uncertainty_score":0.01074362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01079519659550693,"score_gpt":0.2610147020802349,"score_spread":0.2502195054847279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}