{"id":"W4281289944","doi":"10.1101/2022.05.06.22274690","title":"Phase I study of a SARS-CoV-2 mRNA vaccine PTX-COVID19-B","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; University of New Brunswick; Manna Research; Canada Research Chairs; Providence Health Care","funders":"Sunnybrook Research Institute","keywords":"Immunogenicity; Adverse effect; Tolerability; Neutralizing antibody; Medicine; Placebo; Virology; Titer; Antibody; Immunology; Pharmacology; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001057033,0.0013761,0.001714018,0.000364059,0.0003662507,0.000801836,0.0008365585,0.001288535,0.005475355],"category_scores_gemma":[0.0008988107,0.0005160086,0.0007276859,0.0003047879,0.0006371138,0.0006547896,0.0002633734,0.002193514,0.001095053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005818076,"about_ca_system_score_gemma":0.001424919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006331134,"about_ca_topic_score_gemma":0.0008902356,"domain_scores_codex":[0.9995762,0.0001481157,0.00002330939,0.0001017027,0.00006266245,0.00008798911],"domain_scores_gemma":[0.9994441,0.00008102872,0.0001308488,0.00006117862,0.00007665371,0.0002062911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6512805,0.1086021,0.002307727,0.001518176,0.000821062,0.0002324484,0.0002332549,0.001561788,0.1621544,0.0004678391,0.004705559,0.06611515],"study_design_scores_gemma":[0.2875181,0.6972596,0.002984074,0.00004055645,0.0002707191,0.0001151711,0.000044031,0.0005282389,0.007711271,0.0001643186,0.003346051,0.00001785826],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779369,0.002184809,0.002098358,0.0004596187,0.0004005145,0.01196358,0.002433547,0.0002133028,0.002309326],"genre_scores_gemma":[0.9615014,0.003380761,0.004907115,0.001242192,0.0004409237,0.01408485,0.006240566,0.00008411738,0.008118092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005475355,"threshold_uncertainty_score":0.01831686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1024233707133054,"score_gpt":0.4226269057737775,"score_spread":0.3202035350604722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}