{"id":"W4281290631","doi":"10.1161/strokeaha.122.038760","title":"Ethical Justification for Deferral of Consent in the AcT Trial for Acute Ischemic Stroke","year":2022,"lang":"en","type":"review","venue":"Stroke","topic":"Ethics in Clinical Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; St. Michael's Hospital; University of Alberta Hospital; Conference Board of Canada; Foothills Medical Centre; Ottawa Hospital","funders":"","keywords":"Deferral; Medicine; Tenecteplase; Informed consent; Stroke (engine); Ischemic stroke; Intensive care medicine; Alternative medicine; Ischemia; Cardiology; Thrombolysis; Myocardial infarction; Accounting","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch","research_integrity"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.2958776,0.0004930334,0.002578768,0.001713286,0.002495948,0.004949115,0.002786289,0.01476036,0.001678153],"category_scores_gemma":[0.480766,0.000840895,0.002191128,0.002085282,0.008799036,0.004288428,0.002506343,0.01436349,0.0006528346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006193665,"about_ca_system_score_gemma":0.04490405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005036773,"about_ca_topic_score_gemma":0.01221765,"domain_scores_codex":[0.4782794,0.4319817,0.04715711,0.0036967,0.03539508,0.003490103],"domain_scores_gemma":[0.4241109,0.4987912,0.02608345,0.0191993,0.02923051,0.002584608],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0008214247,0.00008821703,0.001477685,0.03260161,0.0006586502,0.0008811072,0.005008215,0.0006072004,0.0006927712,0.5010227,0.1566552,0.2994853],"study_design_scores_gemma":[0.001555226,0.0002901382,0.00266686,0.1166374,0.0006966209,0.001810168,0.0009977106,0.0009464896,0.001086682,0.1337847,0.739352,0.0001759703],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.004373871,0.3417014,0.03274293,0.5471393,0.02537456,0.00455064,0.0005162822,0.00009850919,0.04350248],"genre_scores_gemma":[0.2295828,0.2021476,0.1006761,0.4253348,0.01604461,0.0162436,0.000701824,0.0001251508,0.009143513],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.9852396,"threshold_uncertainty_score":0.8683083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7660098423552691,"score_gpt":0.6619931495938219,"score_spread":0.1040166927614472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}