{"id":"W4281290796","doi":"10.1038/s41467-022-29839-8","title":"Signal requirement for cortical potential of transplantable human neuroepithelial stem cells","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Medical Research Council; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Wellcome Trust","keywords":"Neuroepithelial cell; Progenitor cell; Cell biology; Biology; Stem cell; Neuroscience; Corticogenesis; Forebrain; Cerebral cortex; Cortex (anatomy); Neural stem cell; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001258646,0.0002329419,0.0001369944,0.0002885173,0.00009321284,0.0003622688,0.0001541109,0.0001640473,0.002215094],"category_scores_gemma":[0.0001813992,0.000107478,0.0001494188,0.000100748,0.0001954526,0.0001140208,0.000250654,0.0003756926,0.0005317572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003200678,"about_ca_system_score_gemma":0.0002953967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000690278,"about_ca_topic_score_gemma":0.001280488,"domain_scores_codex":[0.9998633,0.00001966306,0.00001306267,0.00001796414,0.0000573326,0.00002863022],"domain_scores_gemma":[0.9998005,0.00004589812,0.0000456692,0.00001905257,0.00002728203,0.00006159373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006240228,0.00001222282,0.0001765088,0.0000191919,0.000002116349,0.00003091359,0.000007017759,0.00004698213,0.9985923,0.0001082549,0.00002170931,0.0009204113],"study_design_scores_gemma":[0.000006593254,0.00009657571,0.003847258,0.000003952526,0.000005578443,0.0001171143,0.00002023461,0.0004103867,0.9937547,0.00004422064,0.001691494,0.000001825819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910302,0.001524537,0.002708173,0.0001079275,0.00001931237,0.00003269947,0.0005861143,0.0001269611,0.003864078],"genre_scores_gemma":[0.9948201,0.0005207756,0.00142347,0.00003072558,0.000004032349,0.00002750638,0.0006761514,0.00002221128,0.002474904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002215094,"threshold_uncertainty_score":0.007410228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05793919689916764,"score_gpt":0.3013237317979024,"score_spread":0.2433845348987348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}